The present investigation entitled "Ritual practice of the application of the poison of the Acate toad in the Matsés Buenas Lomas Antigua Native Community - 2022", was developed in one of the oldest Communities of the Matsés indigenous people. Its main objective is to describe the healing ritual practice of the resin of the Acate toad in the native community of Matsés Buenas Lomas Antigua. The methodology used in this research was a qualitative approach since it sought to understand the ritual practice of the resin of the toad acate through information narrated by the Matsés actors. For ethnography or data collection technique in the field they were the following: participant observation, unstructured interview and semi-structured interview. To carry out this research, the oldest specialists between 81 and 30 years old, and also the young people between 17 and 29 years old, who admin...