The Central Andes subduction has been the theater of numerous large earthquakes since the beginning of the 21st Century, notably the 2001 Mw = 8.4 Arequipa, 2007 Mw = 8.0 Pisco and 2014 Mw = 8.1 Iquique earthquakes. We present an analysis of 47 permanent and 26 survey global navigation satellite system (GNSS) measurements acquired in Central-South Peru between 2007 and 2022 to better understand the frictional properties of the megathrust interface. Using a trajectory model that mimics the different phases of the cycle, we extract a coherent interseismic GNSS field at the scale of the Central Andes from Lima to Arica (12–18.5°S). Interseismic models on a 3D slab geometry indicate that the locking level is relatively high and concentrated between 20 and 40-km depth. Locking distributions indicate a high spatial variability of the coupling along the trench, with the presence of many lock...