Introduction: COVID-19 vaccines have been essential in controlling the pandemic, but concerns have arisen regarding their adverse effects. This study evaluates the incidence of adverse effects in vaccinated patients attending Pneumology outpatient clinics in the EsSalud Piura network in 2022. Methods: A cross-sectional study was conducted with 254 patients over 18 years of age who received at least one dose of a COVID-19 vaccine (Pfizer, Sinopharm, or AstraZeneca). Data were obtained through a review of medical records and structured interviews. Adverse effects were classified as local or systemic. Crude (RPc) and adjusted prevalence ratios (RPa) were calculated using Poisson models, adjusting for age, sex, comorbidities, and prior COVID-19 infection. Results: Most patients 60.6% were ≤60 years old, and 86.2% had comorbidities. RPa showed that respiratory infection sequelae significant...