Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant inherited neurodegenerative disease, caused by an abnormal CAG trinucleotide expansion in the ATXN2 gene. SCA2 usually occurs in adulthood, with progressive ataxia associated with peripheral neuropathy, impaired eye movements, parkinsonism, and other symptoms. Auxiliary exams include biochemical tests, neuroimaging such as brain MRI, and a molecular genetic study. We describe, for the first time in the Peruvian population, the case of a middle-aged woman with a confirmed diagnosis of SCA2, whose brain MRI shows the “Hot Cross Bun Sign”.

Objetivo: Estimar la sensibilidad y especificidad para amputación de miembro inferior de escalas de pie diabético de estudios realizados en América Latina y el Caribe. Métodos: Se incluyeron estudios tipo cohorte retrospectivos y prospectivos sin restricción de idioma, buscados en las bases de datos Scielo, Embase, PubMed, WOS y SCOPUS. hasta julio de 2023. Los estudios describen la ocurrencia de amputación según un sistema de clasificación basal en pacientes con pie diabético. Sin embargo, no se encontraron estudios que evalúen el pronóstico, por lo tanto, realizamos un meta-análisis de exactitud de pruebas diagnósticas usando STATA 18. Evaluamos el riesgo de sesgo con QUADAS-2 y la certeza de evidencia según GRADE. Resultados: Incluimos 13 artículos que cumplieron los criterios, y pudimos determinar rendimientos diagnósticos para cinco escalas (IDSA, San Elián, WIFI y ...

Objective: To estimate the prognostic accuracy for lower limb amputation using diabetic foot scale studies conducted in Latin America and the Caribbean. Materials and methods: Longitudinal studies were included without language restriction, sourced from Scielo, Embase, PubMed, Web of Science (WOS), and SCOPUS until October 2024. The studies recorded the incidence of major or any-level amputation according to the application of a diabetic foot scale at the onset of medical care. A meta-analysis was conducted to estimate sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), diagnostic odds ratio, and the area under the ROC curve. The risk of bias was assessed using the QUADAS-2 tool, and the certainty of evidence was analyzed according to GRADE. Results: Fifteen articles were included, identifying five scales: IDSA, San Elián, Wifi, Meggitt-Wag...