Background: Studies comparing duodenum-preserving pancreatic head resection versus pancreaticoduodenectomy in the treatment of chronic pancreatitis demonstrate notable differences, however, the current evidence is inadequate to clearly establish the superiority of these approaches. Objective: To determine duodenum preserving pancreatic head resection is more effective than pancreaticoduodenectomy in treating chronic pancreatitis in adults. Material and Methods: A systematic review was conducted identifying and extracting data from seven randomized clinical trials and seven observational studies comparing the efficacy of duodenum-preserving pancreatic resection versus pancreaticoduodenectomy. Results: Bleeding had a mean difference (MD) of -0.18, 95% CI of -0.25 – -0.12, and p < 0.00001. Operative time had an MD of -1.32, 95% CI of -2.20 –      -0.44 and p = 0.003. Hospital st...