Oxygen minimum zones (OMZs) are extended oceanic regions for which dissolved oxygen concentration is extremely low. They are suspected to be expanding in response to global warming. However, currently, the mechanisms by which OMZ varies in response to climate variability are still uncertain. Here, the variability of the subtropical OMZ off central Chile of a regional coupled physical–biogeochemical regional model simulation was analyzed for the period 2000–2008, noting that its fluctuations were significant despite the relatively weak amplitude of the El Niño/Southern Oscillation (ENSO). In particular, the interannual variability in the OMZ volume (OMZVOL, defined as the volume with dissolved oxygen concentration (DO) ≤ 45μM) was approximately 38% larger than that of the seasonal cycle, with maximum and minimum anomalies of OMZVOL taking place during two cold La Niña (LN) years ...