This paper presents the preliminary results of a pilot experiment in which prospective elementary school teachers have to solve arithmetic problems from elementary school textbooks related to the use of fractions through a technological environment. The main objective of the experiment, in addition to assessing the knowledge of the future teachers, is to measure the performance of the students based on the type of feedback received after answering multiple choice questions. The data collected allow us to verify the positive impact of using messages with aids compared to using only correct or error messages. On the other hand, we consolidate a methodology to use the measurement of student reading time provided by the technological environment as a proxy to determine the complexity of verbal problems.

Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)α and IFNγ and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activity and pro-inflammatory target gene expression may be a promising strategy to treat CVDs. Using comparative in silico docking of multiple STAT-SH2 models on multi-million compound libraries, we identi...