Objective. To assess the protective effect of the vaccine against SARS-CoV-2 upon hospitalizations due to COVID-19 during the fourth epidemic wave in Queretaro, Mexico. Methods. This investigation was designed as a retrospective cohort study in patients with COVID-19 during the fourth wave of the epidemic (December 19th, 2021, to January 9th, 2022). The exposed group consisted in those subjects who had received a vaccine against COVID-19 (genetically modified adenovirus vaccine and messenger ribonucleic acid vaccine); and the non-exposed group consisted in those people who were not vaccinated. Diagnosis of COVID-19 was made with a rapid antigenic test in oropharyngeal exudate, and the test was performed between the first and fifth day after the onset of symptoms. All patients who came to healthcare facilities because of symptoms, with a positive test and having received two doses of the ...

Objetivo. Determinar la vacunación como factor protector para hospitalización en paciente con COVID-19 en la cuarta ola de la pandemia. Métodos. Diseño de cohorte retrospectiva en pacientes con COVID-19 durante la cuarta ola (1 enero a 9 febrero de 2022). Grupos expuestos, antecedente de vacuna anti COVID-19 (vacuna de adenovirus modificado genéticamente y vacuna de ácido ribonucleico mensajero), grupo no expuestos, no vacuna. Tamaño de muestra todos los casos del periodo, grupo expuesto (vacuna de adenovirus modificados genéticamente, n=41; vacuna de ácido ribonucleico mensajero, n=105; y grupo no expuesto, n=263. Análisis estadístico, chi cuadrada, riesgo relativo, regresión logística múltiple y cálculo de probabilidad de ocurrencia del evento. Resultados. En una mujer entre 50 y 59 años que no tiene enfermedad crónica degenerativa y que recibió vacuna de adenovirus m...