Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by significantly improving long-term outcomes across multiple malignancies. Despite their benefits, ICIs can lead to immunerelated adverse events, including rare but severe cardiovascular toxicity such as myocarditis, which can be life-threatening. This comprehensive review aims to explore and discuss the mechanisms, clinical presentation, diagnostic challenges, and management strategies of ICI-induced myocarditis, emphasizing the need for early detection and timely intervention. As the use of ICIs continues to expand, further research is essential to fully elucidate the underlying mechanisms and optimize therapeutic strategies to mitigate this potentially fatal complication while maintaining the efficacy of cancer therapy.

Mid-ventricular hypertrophic cardiomyopathy is a rare subgroup within hypertrophic cardiomyopathies that may present with apical aneurysm. This condition is associated with an increased risk of cardiac adverse events, including cardiac arrest, heart failure, thromboembolic events, or sudden cardiac death. We present a case of a 41-year-old man who presented with a history of exertional dyspnea and syncope. Multimodality imaging with echocardiography and cardiac magnetic resonance showed hypertrophy of the mid-ventricular segments with apical aneurysm. An implantable cardioverter-defibrillator was implanted to prevent sudden cardiac death.

Mid-ventricular hypertrophic cardiomyopathy is a rare subgroup within hypertrophic cardiomyopathies that may present with apical aneurysm. This condition is associated with an increased risk of cardiac adverse events, including cardiac arrest, heart failure, thromboembolic events, or sudden cardiac death. We present a case of a 41-year-old man who presented with a history of exertional dyspnea and syncope. Multimodality imaging with echocardiography and cardiac magnetic resonance showed hypertrophy of the mid-ventricular segments with apical aneurysm. An implantable cardioverter-defibrillator was implanted to prevent sudden cardiac death.