La Acantosis nigricans se caracteriza por presentar hiperpigmentación, hiperqueratosis y presencia de papilomatosis Múltiple que afectan en forma simétrica principalmente los pliegues cutáneos. Según etiología se clasifica en dos grandes grupos: benigna y Maligna. En el presente artículo describimos el caso de una Mujer de 42 años afectada de un carcinoma pobremente diferenciado tipo difuso en estómago y paralelamente desarrollo Acantosis Nigricans. Se revisa además la fisiopatología y el posible mecanismo patogénico común de estas manifestaciones dermatológicas en relación a la neoplasia interna.

Introduction: Diseases caused by free-living amoebas (FLA) are rare but with a lethality greater than 90% when they affect the central nervous system (CNS). The clinical picture can be confused with more prevalent diseases. Case report: A 32-year-old farmer from Poroto-Trujillo-La Libertad-Peru, started the disease with a central facial erythematous plaque that was diagnosed as cutaneous tuberculosis (CTB), without improvement despite receiving a complete regimen of anti-tuberculous chemotherapy. Seven months later, he presented severe encephalitis and died three days after his admission to the hospital. FLA trophozoites were found in the skin biopsy. A diagnosis of cutaneous dermatitis due to FLA complicated with granulomatous amebic encephalitis (GAE) is proposed. Similar cases have not been documented in his place of origin. Conclusion: In northern Peru, skin plaques in people exposed...