Compared with other industries, construction has maintained one of the lowest growth rates in productivity and innovation over the last decades. Moreover, low compliance with schedule targets has remained a common issue throughout projects. Therefore, although methodologies developed have benefited productivity in design, construction and operation, meeting client and project objectives becomes challenging without properly integrating organization, information, systems and processes. This perspective introduces the Virtual Design and Construction (VDC) framework. First, this paper studies and reviews VDC since its creation at the Center for Integrated Facility Engineering (CIFE) of Stanford University in 2001. After that, a comprehensive bibliographical review of the VDC framework is presented and updated with examples of its application in construction projects, delving into its element...