Antimicrobials with special considerations for use represent the last line of treatment, therefore, greater control in their consumption is warranted; in order to avoid resistance by microorganisms. Objective: to determine the characteristics of the consumption of antimicrobials with special considerations for use in hospitalized patients of the Regional Hospital of Loreto, period 2019. Methodology: The study was descriptive and the consumption of antimicrobials prescribed to patients of the surgery, gynecology, infectology, medicine and obstetrics, through the defined daily dose. Results: 67.7% of patients treated with antimicrobials with special considerations for use were female, 44.36% of patients were between 30 and 59 years of age, with the month of March being the month with the highest prescription (10.05%) and the most consumed antimicrobial per unit was ceftriaxone sodium 1g (4...