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Adjuvant Pertuzumab and Trastuzumab in Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer in the APHINITY Trial: Third Interim Overall Survival Analysis With Eff...

Publicado por
Loibl, S, Jassem, J, Sonnenblick, A, Parlier, D, Winer, E, Bergh, J, Gelber, RD, Restuccia, E, Im, Y-H, Huang, C-S, Dalenc, F, Calvo, I, Procter, M, Caballero, C, Clark, E, Raimbault, A, Mcconnell, R, Monturus, E, De, Azambuja, E, Gomez, HL, Bliss, J, Viale, G, Bines, J, Piccart, M, Aebi, S, Andersson, M, Bonnefoi, H, Cameron, D, Cardoso, F, de, Haas, S, Dent, S, Fein, L, Frank, E, Gnant, M, Gomez, Moreno, H, Im, S-A, Jackisch, C, Janni, W, Krop, I, Kummel, S, Liu, T-W, Loi, S, Masuda, N, Nili, Gam-Yal, E, Nyawira, B, Pascual, T, Pienkowski, T, Rodríguez-Lescure, A, Suter, T, Thomssen, C, Tjan-Heijnen, V, Tomasello, G, Torres, Ulloa, MR, Twelves, C, Walshe, J, Wilcken, N

Publicado 2024

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Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The APHINITY trial (ClinicalTrials.gov identifier: NCT01358877) previously demonstrated that pertuzumab added to adjuvant trastuzumab and chemotherapy improved invasive disease-free survival (iDFS) for patients with early human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC). Here, we report the preplanned third interim analysis of overall survival (OS) and a descriptive updated iDFS analysis with 8.4 years of median follow-up of 4,804 patients in th...