We determined the main parameters of the source rupture process of intermediate- and deep-depth earthquakes occurring in the Peru–Brazil–Bolivia border region and northern Chile. The parameters of depth, fault-plane orientation, scalar seismic moment, slip distribution, and radiated seismic energy are obtained from seismograms. We selected 15 intermediate-depth earthquakes (100 km < h < 300 km) and 10 very deep earthquakes (h > 500 km) with magnitudes MW ≥ 6.0. For most events, the slip distribution over the rupture plane shows a single asperity, and the source time function presents a simple pulse. There are differences between intermediate-depth and deep earthquakes. The rupture areas, maximum slip and source time function (STF) duration are larger for intermediate-depth events than for deep events. Additionally, the STF’s show a sharper increase for deep earthq...