Introduction. Snakebite envenomation is a public health problem worldwide and in Peru. Its current treatment relies on antivenoms produced in mammals; however, snake venom phospholipases A2 (PLA2) cause diverse and often irreversible toxic effects, highlighting the need for alternative therapies such as plant extracts.Objective. To evaluate the antioxidant capacity of lyophilized aqueous extracts of Piper aduncum (matico) and Plantago major (llantén), as well as their inhibitory action on the PLA2 from Lachesis muta venom. Methods. An in vitro experimental study was conducted with PLA2 purified by chromatography. Antioxidant activity was determined using DPPH and FRAP assays, and phenolic and flavonoid contents were quantified. Enzymatic inhibition was assessed with lyophilized aqueous extracts and fraction 4 from each sample. Results. Fractions inhibited purified PLA2 activity by 78.08...