The current COVID-19 pandemic is generating multiple changes in the country's health reality, including situations typical of the nursing professional practice and its environment. Objective: To determine the relationship between occupational risk and work stress in nurses who care for patients with COVID-19 in Emergency at the National Institute of Neoplastic Diseases (INEN). Methodology: The study had a quantitative, correlational, cross-sectional and non-experimental design approach. The population consisted of 58 nurses working in the INEN Emergency Service (Lima-Peru). Two instruments were used: "Questionnaire to measure occupational risk in nurses" and the "Scale for measuring work stress in nurses". Results: 46.6% of the participants presented a high occupational risk level, 43.1% medium risk and 10.3% low occupational risk. The biological risk and psychosocial risk showed a mainl...