As a consequence of on-going global warming, the ocean is losing oxygen, which has implications not only in terms of marine resources management and food supply but also in terms of the potentially important feedback on the global carbon cycle and climate. Of particular scrutiny are the extended zones of already low levels of oxygen called the oxygen minimum zones (OMZs) embedded in the subsurface waters of the productive Eastern Boundary Upwelling Systems (EBUS). These OMZs are currently diversely simulated by state-of-the-art Earth System Models (ESM) hampering a reliable projection of ocean deoxygenation on marine ecosystem services in these regions. Here we focus on the most emblematic EBUS OMZs of the planet, that of the South Eastern Pacific (SEP), which is under the direct influence of the El Niño Southern Oscillation (ENSO), the main climate mode on interannual timescales at glo...