Traditionally Hirschsprung´s disease has been diagnosed and treated under the paradigm of the absence of submucosal and myenteric nerve plexus in a localized area of the colon. Surgical treatment consists of resection of the aganglionic area and anastomosis of the anal level of the ganglionic region of  the colon. The review of the long-term results of the surgery, with the various surgical techniques existing up to now show complications related to incontinence and constipation in about 50 % of the cases. Many surgeons think that this disease is still unknown and even incurable. With the advancement in the field of research in molecular biology in the been discovered that addition to the absence of the nerve plexuses, and the Cajal cells in the aganglionic segment, failure in the secretion of mediators called purinergic, such as the ATP and its receptors, as well nitrate sub...

Introduction: In the Surgical treatment of giant omphalocele and gastroschisis and recommended the complementary treatment with prosthetic synthetic patch in order to prevent the compartmental syndrome. But this prosthetic materials are get out seven a twelve days post surgery. Objectives: This study has the goal to determinate the usefulness of a porcine pericardium treated with 1 % glutaraldehyde , surgically applied on a defect in the abdominal wall. Matrial and method: The study was carry on in Experimental Surgery Unit at the National Child Hospital , we've had 30 rats Holtzmann with weights between 200 and 300 grams. The porcine pericardium sterile obtained was treated with 1% glutaraldehyde. The animals were anesthesied with ketamine 50 mg/ kg and Xilascina 12 mgs/kg IM Atropine 0.2 mgs/Kilo IM. Using sterile surgical technical a rectangular area of 3 x 1 centimeter of the abdomin...

Introduction: In the Surgical treatment of giant omphalocele and gastroschisis and recommended the complementary treatment with prosthetic synthetic patch in order to prevent the compartmental syndrome. But this prosthetic materials are get out seven a twelve days post surgery. Objectives: This study has the goal to determinate the usefulness of a porcine pericardium treated with 1 % glutaraldehyde , surgically applied on a defect in the abdominal wall. Matrial and method: The study was carry on in Experimental Surgery Unit at the National Child Hospital , we've had 30 rats Holtzmann with weights between 200 and 300 grams. The porcine pericardium sterile obtained was treated with 1% glutaraldehyde. The animals were anesthesied with ketamine 50 mg/ kg and Xilascina 12 mgs/kg IM Atropine 0.2 mgs/Kilo IM. Using sterile surgical technical a rectangular area of 3 x 1 centimeter of the abdomin...

Existen situaciones quirúrgicas en cirugía pediátrica como es el caso del onfalocele y la gastrosquisis en que una vez reducido el contenido intestinal, no se puede cerrar la pared abdominal sin producir un síndrome compartimental que afecte la vida del paciente. Existen parches artificiales de poliéster, vycril, o pefluortetraetileno que pueden utilizarse para ampliar la cavidad abdominal, pero debido a su elevado costo no se pueden utilizar en nuestros pacientes; por lo que se hace necesario estudiar tejidos, que permitan una terapia alternativa a las prótesis artificiales. El objetivo del presente trabajo es determinar la eficacia de un parche de fascia lata humana tratada con gluteraldehído aplicada epiaponeuroticamente sobre un defecto de 1.5 x 2 cms practicado sobre la pared abdominal. El estudio se realizó en 21 ratas de la raza sprague male con pesos de 200 a 300 grs, las...

 Traditionally Hirschsprung´s disease has been diagnosed and treated under the paradigm of the absence of submucosal and myenteric nerve plexus in a localized area of the colon. Surgical treatment consists of resection of the aganglionic area and anastomosis of the anal level of the ganglionic region of  the colon. The review of the long-term results of the surgery, with the various surgical techniques existing up to now show complications related to incontinence and constipation in about 50 % of the cases. Many surgeons think that this disease is still unknown and even incurable. With the advancement in the field of research in molecular biology in the been discovered that addition to the absence of the nerve plexuses, and the Cajal cells in the aganglionic segment, failure in the secretion of mediators called purinergic, such as the ATP and its receptors, as well nitrate sub...