Introduction.Melanoma is a public health problem; it represents 4% of malignant skin tumors and is responsible for 80% of deaths from this type of neoplasm. Objective: Show the response to Temozolomide in patients with metastatic melanoma. Methods: Descriptive, cross-sectional study. The clinical response of patients with metastatic melanoma, managed with Temozolomide 200 mg/m2 once a day was analyzed for 5 days every 28 days. The risk factors analyzed were: histological variety, topographic region of the primary lesion, metastasis, ulceration, and Breslow. Descriptive statistics were used for normality Kolmogorov-Smirnoff, Student's t-test, and binary logistic regression. Results: There were 51 les, 47 met the criteria; 25 men, 22 women, mean age 54.45, minimum 22, maximum 85 years, Complete response was obtained in 3 (6.3%), partial response in 7 (14.8%), stable disease in 10 (21%) and...

Objective: To compare the effectiveness of stratifying high cardiovascular disease (CVD) risk inpatients diagnosed with rheumatoid arthritis (RA) using the Framingham Risk Score (FRS), modifiedSystematic Coronary Risk Evaluation (mSCORE), 2013 American College of Cardiology/AmericanHeart Association (2013 ACC/AHA) guidelines and QResearch Risk Estimator version 3 (QRISK3),with carotid ultrasound (CUS) serving as the gold standard for detecting subclinical atherosclerosis.Materials and methods: A comparative, observational and cross-sectional diagnostic study was conducted in patients aged 40 to 75 years, of both sexes, with RA and without CVD, at a tertiarycare hospital in Puebla, Mexico. Patients on treatment with one or more disease-modifying antirheumatic drugs (DMARDs) for at least three months were included. Patients with chronic diseases and those who did not undergo a CUS were exc...