Abstract Objective: To determine clinical and biochemical characteristics in type 2 diabetes mellitus (T2DM) in pediatric patients at time of diagnosis. Design: Clinical retrospective study. Setting: Endocrinology Service, Instituto Nacional de Salud del Niño, Lima, Peru. Patients: Children with diabetes mellitus type 2. Methods: Medical records of 187 registered patients with diabetes mellitus were reviewed and 17 (9%) with T2DM were identified. Personal and familiar characteristics, symptoms and biochemical data were obtained. Main outcome measures: Clinical and biochemical characteristics of pediatric patients. Results: Average age at diagnosis was 12.8±3 years, 11 were male (64.7%) and 6 female (35.3%). All were born at term and 17.6% were macrosomic. Fourteen patients (82.4%) had a family history of T2DM. Most frequent symptoms were polyuria, polydipsia, polyphagia and weight loss...

La nefropatía constituye la complicación más grave de la diabetes mellitus tipo 1 (DMt1) siendo una de las manifestaciones iniciales la microalbuminuria. Objetivos: Determinar el comportamiento de los factores epidemiológicos, clínicos y bioquímicos en el desarrollo de microalbuminuria en pacientes con DMt1. Diseño: Estudio de casos y controles. Lugar: Servicio de Endocrinología del Instituto Nacional de Salud del Niño, Lima, Perú. Participantes: Pacientes diabéticos tipo 1 menores de 18 años. Intervenciones: Se estudió 64 pacientes portadores de DMt1, 22 con microalbuminuria y 42 sin esta manifestación, que constituyeron los casos y controles respectivamente. Se consignó como factores epidemiológicos la edad al diagnóstico, tiempo de evolución, género, antecedentes familiares de diabetes, nefropatía, dislipidemia, hipertensión arterial; como factores clínicos, el e...

Objectives: To describe the clinical and biochemical response to treatment of hyperthyroidism. Design: Retrospective study. Setting: Instituto Nacional de Salud del Niño, Lima, Peru. Participants: children. Methods: From 1996 to 2007 32 patients with diagnosis of hyperthyroidism were studied. Remission was defined when patients were asymptomatic and biochemically euthyroid 6 months after the end of treatment; relapse when altered hormone levels were found after this period of time. Main outcome measures: Remission or relapse following treatment. Results: Mean age at diagnosis was 10.5 years (3.2-17.9 years), 26 patients (81.2 %) were female; 13 (40.6 %) were pubertal and 18 (59.3%) prepubertal. The most frequent symptoms and signs were: goiter, sweating, nervousness, weight loss, tachycardia and exophthalmos. Methimazole was used as first therapeutic option. Initial dose was 0.78mg/kg/d...