The determination of phenolic compounds and antioxidant activity of grape pomace (Vitis vinifera) of two varieties: Quebranta (red) and Torontel (white) using two drying methods: freeze drying and cool air-drying was evaluated, using methods to preserve and maintain bioactive compounds like polyphenols and their antioxidant capacity, these are DPPH and FRAP assays. In general, according to solvent extraction for both grape pomace varieties using the two drying methods, there were obtained high contents of extractable, hydrolysable and condensed tannins polyphenols and therefore exhibited high antioxidants capacities. However, Torontel grape pomace variety obtained by cool air-drying was better in extractable polyphenols, DPPH· and FRAP assays, than those obtained by freeze drying, being 6,095.36 ± 0.58 mg GAE/100 g pomace, 4,042.57 ± 27.80 mg pomace/g DPPH·, 390.23 ± 7,14 µM Trolox...