Se evaluó la actividad antitumoral y antiviral de los extractos al 10% p/v de hojas y corteza de Calophylum brasiliense Cambess de Satipo y Pucallpa. Se utilizaron técnicas del CYTED, Skehan y Simmons. En Artemia salina la CL50 fue 70.5 ppm, con un limite superior e inferior al 95% de 136.50ppm y de 36.4ppm por Probits, asimismo se observó una inhibición sobre líneas celulares tumorales: U251(Cáncer del SNC), PC-3(Cáncer de Próstata), HCT15 (Cáncer de Colon), MCF7(Cáncer de Mama) y K562 (Cáncer de Tejido Linfoide) de 109.42%, 95.67%, 96.16%, 102.68% y 95.69% respectivamente, con una p< 0,01. En la evaluaciòn antimitòtica en cebolla, al cabo de 6 horas el IM de las células meristemáticas decreció de 13 a 1.0 a la concentración de 0.5% a 25ºC. La actividad antiviral sobre la Transcriptasa Reversa (RT) del HIV-1, realizada con el Kit Lenti RT, presentó una CL50 de 70.2...

The purpose of the present investigation has been to evalue DL50 and effective dose average DE50 of antiinflamatory effect of the methanolic extract of the leavs of Pelargonium robertianum L «Geranio». To evaluate the DL50, 36 mice were used and divided in groups of 6 animals; administe doses different from the methanolic extract by oral route by means of intragastric cannulas, observed constantly during the firts 24, 48 and 72 hours. The value of the DL50 was of 8,717.0 mg/kg by Lichfield and Wilcoxon Method. Also to evaluate the DE50, following Winter and Sughisita technique, 50 male albine rats.The weight average ranged between 200 to 250g. and were divided randomly in 5 groups of experimentation:I G, Negative Control (Distilled Water, 3 ml/kg) II G, Positive control (Diclofenac, 10 mg/kg); III, IV and V Groups were given 250, 500 y 1000 rng/kg respectively. The administration was m...

The purpose of the present investigation has been to evalue DL50 and effective dose average DE50 of antiinflamatory effect of the methanolic extract of the leavs of Pelargonium robertianum L «Geranio». To evaluate the DL50, 36 mice were used and divided in groups of 6 animals; administe doses different from the methanolic extract by oral route by means of intragastric cannulas, observed constantly during the firts 24, 48 and 72 hours. The value of the DL50 was of 8,717.0 mg/kg by Lichfield and Wilcoxon Method. Also to evaluate the DE50, following Winter and Sughisita technique, 50 male albine rats.The weight average ranged between 200 to 250g. and were divided randomly in 5 groups of experimentation:I G, Negative Control (Distilled Water, 3 ml/kg) II G, Positive control (Diclofenac, 10 mg/kg); III, IV and V Groups were given 250, 500 y 1000 rng/kg respectively. The administration was m...

The present investigation was done to evaluate lethal dose fifty (DL50) and effective dose average (DE50) of the antiinflammatory effect of a methanolic extract of the leaves of Pelargonium robertianum L."Geranio". To evaluate the DL50, 36 mice were used, divided in groups of 6 animals that received different doses of the methanolic extract by oral route using intragastric cannulae. Animals were observed during the first 24, 48 and 72 hours. The value of the DL50 was of 8,717.02 mg/kg by the Lichfield and Wilcoxon method. DE50 following Winter's Model (1970) and Sughisita et.al. was also performed. We observed that the methanolic extract presented an inhibitory effect of inflammation when compared to that of Diclofenac (62%) obtaining 26, 38 and 57% for the different doses assayed. The Average Effective Dose obtained was of 681,9577 by the method of Probits with ANOVA (p=0.0001,F=5240, R...

Evaluamos la acción antinociceptiva del extracto metanólico del Chuchuhuasi (Maytenus krukovii), al 20%, administrado por vía oral, en ratones albinos, machos, raza Webster Suizo obtenidos del Centro Nacional de Producción de Biológicos del Ministerio de Salud del Perú, utilizando un modelo de dolor visceral, mediante la administración de ácido acético al 2%, vía intraperitoneal, a la dosis de 0,05 ml/10g de peso. Observamos una disminución del 50% del número de contorsiones abdominales, en relación al grupo control, sin prolongación del período de latencia de las mismas. El efecto analgésico observado, fue bloqueado por la naloxona, lo que sugeriría la participación de receptores opioides, o de opioides endógenos en el mecanismo de la acción analgésica. Los resultados fueron analizados estadísticamente mediante el programa estadístico SPSS versión 11.5.