The purpose of the present investigation has been to evalue DL50 and effective dose average DE50 of antiinflamatory effect of the methanolic extract of the leavs of Pelargonium robertianum L «Geranio». To evaluate the DL50, 36 mice were used and divided in groups of 6 animals; administe doses different from the methanolic extract by oral route by means of intragastric cannulas, observed constantly during the firts 24, 48 and 72 hours. The value of the DL50 was of 8,717.0 mg/kg by Lichfield and Wilcoxon Method. Also to evaluate the DE50, following Winter and Sughisita technique, 50 male albine rats.The weight average ranged between 200 to 250g. and were divided randomly in 5 groups of experimentation:I G, Negative Control (Distilled Water, 3 ml/kg) II G, Positive control (Diclofenac, 10 mg/kg); III, IV and V Groups were given 250, 500 y 1000 rng/kg respectively. The administration was m...

The purpose of the present investigation has been to evalue DL50 and effective dose average DE50 of antiinflamatory effect of the methanolic extract of the leavs of Pelargonium robertianum L «Geranio». To evaluate the DL50, 36 mice were used and divided in groups of 6 animals; administe doses different from the methanolic extract by oral route by means of intragastric cannulas, observed constantly during the firts 24, 48 and 72 hours. The value of the DL50 was of 8,717.0 mg/kg by Lichfield and Wilcoxon Method. Also to evaluate the DE50, following Winter and Sughisita technique, 50 male albine rats.The weight average ranged between 200 to 250g. and were divided randomly in 5 groups of experimentation:I G, Negative Control (Distilled Water, 3 ml/kg) II G, Positive control (Diclofenac, 10 mg/kg); III, IV and V Groups were given 250, 500 y 1000 rng/kg respectively. The administration was m...

The present investigation was done to evaluate lethal dose fifty (DL50) and effective dose average (DE50) of the antiinflammatory effect of a methanolic extract of the leaves of Pelargonium robertianum L."Geranio". To evaluate the DL50, 36 mice were used, divided in groups of 6 animals that received different doses of the methanolic extract by oral route using intragastric cannulae. Animals were observed during the first 24, 48 and 72 hours. The value of the DL50 was of 8,717.02 mg/kg by the Lichfield and Wilcoxon method. DE50 following Winter's Model (1970) and Sughisita et.al. was also performed. We observed that the methanolic extract presented an inhibitory effect of inflammation when compared to that of Diclofenac (62%) obtaining 26, 38 and 57% for the different doses assayed. The Average Effective Dose obtained was of 681,9577 by the method of Probits with ANOVA (p=0.0001,F=5240, R...