INTRODUCTION. Early prenatal diagnosis of chromosomal anomalies requires invasive techniques such as amniocentesis and chorionic villous sampling. We present our experience and the predictive value of ultrasonographic risk markers. DESIGN. Descriptive, transversal study. SETTING. Instituto Latinoamericano de Salud Reproductiva, Lima, Peru. BIOLOGIC SAMPLES. Amniotic fluid and placenta. INTERVENTIONS. We analyzed the results of 163 amniocentesis and 12 chorionic villous sampling performed at our institute between January 2003 and September 2007. MAIN OUTCOME MEASURES. Chromosome anomalies. RESULTS. The most frequent indication for prenatal invasive techniques was maternal age above 38 years; 48 (27,9%) of the samples obtained were positive for chromosomal anomalies and trisomy 21 the most common finding. The highest frequency of chromosomal anomalies was found in pregnancies with more tha...

INTRODUCTION. Early prenatal diagnosis of chromosomal anomalies requires invasive techniques such as amniocentesis and chorionic villous sampling. We present our experience and the predictive value of ultrasonographic risk markers. DESIGN. Descriptive, transversal study. SETTING. Instituto Latinoamericano de Salud Reproductiva, Lima, Peru. BIOLOGIC SAMPLES. Amniotic fluid and placenta. INTERVENTIONS. We analyzed the results of 163 amniocentesis and 12 chorionic villous sampling performed at our institute between January 2003 and September 2007. MAIN OUTCOME MEASURES. Chromosome anomalies. RESULTS. The most frequent indication for prenatal invasive techniques was maternal age above 38 years; 48 (27,9%) of the samples obtained were positive for chromosomal anomalies and trisomy 21 the most common finding. The highest frequency of chromosomal anomalies was found in pregnancies with more tha...

Objectives: To determine the feasibility of cervical length measurement by transabdominal ultrasound at 20-23 weeks of gestation and to correlate this measurements with those obtained by tansvaginal ultrasound. Design: Observational cross-sectional study. Setting: Instituto Latinoamericano de Salud Reproductiva (ILSAR), Lima, Peru. Participants: Pregnant women. Methods: In 67 pregnant women with no risk factors for preterm delivery (PTD) measurement of the uterine cervix at 20-23 weeks of gestation was performed. Thirty women (30) underwent both transabdominal and transvaginal ultrasound measurement. Main outcome measures: Correlation of uterine cervix measurement by abdominal and transvaginal ultrasound. Results: The cervix could be measured satisfactorily by transabdominal measurement in 65 women (97%). There was a good correlation between transabdominal and transvaginal measurement  ...

Objectives: To assess the feasibility of measuring cervical by transabdominal ultrasound between 20 and 23 weeks of gestation and compare these measurements with those obtained by transvaginal ultrasound. Design: Cross-sectional study. Setting: Instituto Latinoamericano de Salud Reproductiva (ILSAR), Lima, Peru. Participants: Normal pregnant women with no risk factors for preterm delivery (PTD). Methods: Cervical length was measured to 67 normal pregnant women 20-23 weeks by transabdominal ultrasound. In 30 women cervical length was measured by abdominal ultrasound using 3-5 MHZ convex transducer and by vaginal ultrasound with 5-7 MHZ endotransducer. Main outcome measures: Cervical length measurement. Results: The cervix was satisfactorily measured by transabdominal ultrasound in 65 women (97%). There was good correlation between transabdominal and transvaginal measurement (r<....

Objectives: To assess the feasibility of measuring cervical by transabdominal ultrasound between 20 and 23 weeks of gestation and compare these measurements with those obtained by transvaginal ultrasound. Design: Cross-sectional study. Setting: Instituto Latinoamericano de Salud Reproductiva (ILSAR), Lima, Peru. Participants: Normal pregnant women with no risk factors for preterm delivery (PTD). Methods: Cervical length was measured to 67 normal pregnant women 20-23 weeks by transabdominal ultrasound. In 30 women cervical length was measured by abdominal ultrasound using 3-5 MHZ convex transducer and by vaginal ultrasound with 5-7 MHZ endotransducer. Main outcome measures: Cervical length measurement. Results: The cervix was satisfactorily measured by transabdominal ultrasound in 65 women (97%). There was good correlation between transabdominal and transvaginal measurement (r&l...

Background: Nuchal cystic hygroma is the most frequently identified marker of chromosomal anomalies during first trimester screening. Objective: To determine the association of the nuchal cystic hygroma with chromosomal anomalies diagnosed with karyotyping done between the first and second trimesters of pregnancy. Design: Retrospective study. Setting: Instituto Latinoamericano de Salud Reproductiva (ILSAR), Lima, Peru. Patients. Fetuses with nuchal cystic hygroma. Methods: The data were obtained from the ILSAR database between August 2007 and May 2018, the cases diagnosed by ultrasound from week 11 to 13.6. Nuchal cystic hygroma was defined as the presence of septated liquid content in the nuchal axial section with a thickness above the 95th percentile value for increased nuchal translucency value for the crown-rump length. The karyotype was obtained between the first and second trimeste...

Introduction: Early prenatal diagnosis of chromosomal abnormalities requires invasive techniques, including chorionic villous sampling (CVS) and amniocentesis (AMC) in order to acquire, culture and kayotype cells from fetuses at high risk for these abnormalities based on sonographic and biochemical markers present after week 11. We report our experience through June 2016.Design: Descriptive, longitudinal study. Setting: Instituto Latinoamericano de Salud Reproductiva (ILSAR), Lima, Peru. Participants: First and second trimester of pregnancy fetuses. Interventions: Results of the study of 400 first and second trimester fetuses at high risk for chromosomal abnormalities (greater than 1/270 initially or 1/100 starting in 2012) based on Spain Fetal Test database and the results of biochemical markers (combined risk). Fetal karyotype analysis was performed on samples obtained from 338 genetic...