Water is an essential resource for social and economic development. The availability of this resource is constantly threatened by the rapid increase in its demand. This research assesses current (2010–2016), short- (2017–2040), middle- (2041–2070), and long-term (2071–2099) levels of water security considering socio-economic and climate change scenarios using the Water Evaluation and Planning System (WEAP) in Vilcanota-Urubamba (VUB) catchment. The streamflow data of the Pisac hydrometric station were used to calibrate (1987–2006) and validate (2007–2016) the WEAP Model applied to the VUB region. The Nash Sutcliffe efficiency values were 0.60 and 0.84 for calibration and validation, respectively. Different scenarios were generated for socio-economic factors (population growth and increased irrigation efficiency) and the impact of climate change to evaluate their effect on the...