Objectives The objective of this study was to perform a systematic review and meta‐analysis of the literature to evaluate the efficacy and safety of therapies for cerebral toxoplasmosis in HIV ‐infected adults. The pyrimethamine plus sulfadiazine (P‐S) combination is considered the mainstay therapy for cerebral toxoplasmosis and pyrimethamine plus clindamycin (P‐C) is the most common alternative treatment. Although trimethoprim‐sulfamethoxazole (TMP ‐SMX ) has potential advantages, its use is infrequent. Methods We searched PubMed and four other databases to identify randomized controlled trials (RCT s) and cohort studies. Two independent reviewers searched the databases, identified studies and extracted data. Risk ratios (RR s) were pooled across studies using random‐effects models. Results Nine studies were included (five RCT s, three retrospective cohort studies and one ...

Purpose: Adaptive servoventilation (ASV) has been reported to show improvement in patients with sleep-disordered breathing (SDB) and heart failure (HF); however, its role as a second-line or adjunctive treatment is not clear. We conducted a systematic review and meta-analysis of new existing data including cardiac mechanistic factor, geometry, and cardiac biomarkers. Methods: We systematically searched for randomized controlled trials (RCTs) and cohort studies that assessed the efficacy or effectiveness of ASV compared to conventional treatments for SDB and HF in five research databases from their inception to November 2018. Random-effects meta-analyses using the inverse variance method and stratified by study design were performed. Results: We included 15 RCTs (n = 859) and 5 cohorts (n = 162) that met our inclusion criteria. ASV significantly improved left ventricular ejection fraction...

This study was made possible through the financial support of the Instituto Nacional de Salud (National Institute of Health, Lima, Peru) and the PROVAC Initiative of the Pan American Health Organization (Washington, DC, USA). This study was presented at 9th International Symposium of Pneumococci and Pneumococcal Diseases, Hyderabad, India, March 2014, and supported by the National Council of Science, Technology and Technological Innovation of Peru (CONCYTEC) and International Clinical Epidemiology Network (INCLEN Trust).