Canine visceral leishmaniasis (CVL), caused by Leishmania infantum (Ross, 1903), is an emerging disease in Uruguay, posing significant public and animal health challenges. This study aimed to evaluate the relationship between clinical signs and hematological, hepatic, and renal alterations in dogs seropositive for L. infantum in Uruguay. Canids were classified according to the absence/presence of clinical signs as asymptomatic (no apparent signs of disease), oligosymptomatic (less than three clinical signs compatible with CVL), polysymptomatic (three to six clinical signs), and hypersymptomatic (with more than six clinical signs). Laboratory analysis revealed significant alterations in hematological, hepatic, and renal parameters as the number of clinical signs increased. Polysymptomatic and hypersymptomatic dogs exhibited significant decreases in erythrocytes, hemoglobin, hematocrit, me...