The study of Chemistry in high school often faces various difficulties that affect understanding and academic performance, which may arise from conceptual complexity, lack of connection with daily life, and traditional educational methodology. Objective: To understand the difficulties of students in learning Chemistry during high school, from their perspective, and to identify didactic alternatives used to overcome them. Methodology: A mixed approach with exploratory-descriptive scope, non-experimental, cross-sectional cohort was used, employing survey technique on the total sample (120 students), consisting of 12 thematic blocks and 12 items, aiming to understand the difficulties from students' perspective with a reliability of 0.835 in Cronbach's Alpha. Results: The results revealed that the most common difficulties include lack of motivation, abstraction of chemical concepts, topics r...