In order to facilitate the understanding of tools that monitor general health, we developed a systematic review of the Goldberg General Health Questionnaire (GHQ-28) to determine the risk factors that explain the psychological problems that were identified in the general population. Previously, a bibliometric approach was carried out to identify research trends on the scientific literature of the GHQ-28. We use Web of Science and Scopus as information sources to retrieve scientific production on GHQ-28, from 2016 and 2021 in English and Spanish. We retrieved 45 studies obtained by search equations, including only 33 systematic review studies after applying the inclusion and exclusion criteria. A massive increase in post-covid-19 pandemic mental health problems was identified, being reported using the GHQ-28 instrument. Common risk factors are identified that inform mental health deterior...