We report the case of a male teenager with the classical clinical picture of McCune-Albright syndrome, with precocious puberty, cafe-au-lait spots, polyostotic fibrous dysplasia and gigantism. Magnetic resonance images are described and a review of the respective literature is also presented.

Bisphosphonates are antiresorptive agents with high affinity for hidroxiapatite crystals. They are not degraded by pyrophosphatases. Their main indications are treatment of post-menopausic osteoporosis, corticosteroid-induced osteoporosis, Paget´s disease, neoplasm-induced hypercalcemia and osteolytic bone disease by cancer.

Here, we present a brief historical background and address the importance of the use of metformin in the treatment of non-insulin dependent diabetes mellitus, based in the european and canadian experience. We recommended a dose of 500 mg, because there has been showed that the incidence of lactic acidosis is very low, a good dose completion is reached, and it can be combined with other oral antidiabetic drugs.

El objetivo general del trabajo de investigación fue determinar la relación de los costos y la seguridad en los procesos notariales de separación y divorcio ulterior y su relación con la eficacia en los divorcios en la ciudad de Lima. El tipo de investigación fue descriptivo y el nivel aplicado, el método y diseño de investigación fue correlacional. La población fue censal y estuvo compuesta por 60 notarios y colaboradores de oficios notariales de las Notarías del Cercado de Lima

El síndrome costillas cortas polidactilia es una categoría descriptiva para un grupo de displasias esqueléticas incompatibles con la vida, caracterizadas por tórax estrecho, costillas extremadamente pequeñas, micromelia, polidactilia y anomalías viscerales. Las 4 variantes establecidas son SRPS I (tipo Saldino-Noonan), SRPS II (tipo Majewski), SRPS III (tipo Verma-Naumoff) y SRPS IV (tipo Beemer-Langer). Se piensa que todas las variantes son heredadas en forma autosómica recesiva. Debido a la frecuente superposición fenotípica, existe controversia si las variantes son debidas a expresión variable o a heterogeneidad genética. Presentamos un caso de un feto masculino, con signos ecográficos característicos de displasia esquelética, tales como micromelia, tórax estrecho en forma de campana, hipertelorismo, implantación baja de las orejas y polidactilia, que nació de parto v...

Placental mesenchymal dysplasia is a rare condition of placentomegaly and abnormal chorionic villous, often clinically confused as partial hydatidiform mole. However, it is different clinically and pathologically, with high incidence of intrauterine growth restriction and stillbirth. We present the clinical course of a pregnant woman carrying placental mesenchymal dysplasia, the first case diagnosed at the Maternal Perinatal National Institute, how to suspect diagnosis and gestational care. There was need for caesarean section at 27 weeks gestation, obtaining a 1 048 g newborn girl, with Apgar 8 at the first minute and 9 at the fifth minute, bloody amniotic fluid in regular quantity and placentomegaly. Patient evolved satisfactorily and was discharged on the third hospitalization day. An abdominal liver tumor was confirmed in the newborn and surgical pathology report was liver mesenchyma...

We present a case of siamese twins diagnosed by ultrasound as thoraco-omphalopagus joint fetuses, at Instituto Nacional Materno Perinatal (Ex Maternidad de Lima). We summarize the clinical history, necropsy protocol and present a short bibliography.

We present a case of siamese twins diagnosed by ultrasound as thoraco-omphalopagus joint fetuses, at Instituto Nacional Materno Perinatal (Ex Maternidad de Lima). We summarize the clinical history, necropsy protocol and present a short bibliography.