1
artículo
Publicado 2025
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Necrotizing fasciitis is a progressively destructive infectious disease that affects the soft tissues. It is an uncommon condition associated with 10-40% mortality rates that can be as high as 80-100% if untreated. Limited information exists on this infection involving the face. We present the case of a 63-year-old male patient with no relevant past medical history who attended the emergency room with right facial and cervical edema, fever, pain, and a yellow plaque-like lesion on the periorbital area. Surgical and medical treatment were implemented. It is relevant to present this unusual clinical entity to increase awareness.
2
artículo
Publicado 2015
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The essential oil (EO) obtained from the leaves and flowers of Hyptis suaveolens (L.) Poit. collected from Guasdualito, Apure State, Venezuela. Oil was obtained by hydrodistillation using a Clevenger trap. The oil was analyzed by gases chromatography-mass spectrometry (GC/MS). Thirty-five compounds were identified in the leaves (91.9% of the sample) and thirty compounds in the flowers (97.0% of the sample), the major compounds: 1,8-cineole (19.1% leaves, flowers 13.3%), fenchone (18.5% leaves, flowers 16.1%), bicyclogermacrene (12.7% leaves, flowers 18.8%), D-germacrene (6.3% leaves, flowers 10.0%). The antibacterial activity was evaluated by the agar diffusion method with disks against Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, ATCC 23357 Klebsiella pneumoneae, Salmonella typhi CDC 57, Pseudomonas aeruginosa ATCC 27853. Both EO inhib...
3
artículo
Publicado 2015
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El aceite esencial (AE) obtenido de las hojas y flores de Hyptis suaveolens (L.) Poit. recolectado en Guasdualito, Estado Apure, Venezuela, fue obtenido por hidrodestilación empleando una trampa de Clevenger. El aceite se analizó mediante cromatografía de gases acoplada a espectrometría de masas (GC/MS), se identificaron treinta y cinco compuestos en las hojas (91.9% de la muestra) y treinta compuestos en las flores (97.0% de la muestra), con los siguientes compuestos principales: 1,8-cineol (19.1% hojas, 13.3% flores), fenchona (18.5% hojas, 16.1% flores), biciclogermacreno (12.7% hojas, 18.8% flores), D-Germacreno (6.3% hojas, 10.0% flores). La actividad antibacteriana se evaluó por el método de difusión en agar con discos contra Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 23357, Salmonella typhi CDC...
4
artículo
Publicado 2024
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BACKGROUND AND OBJECTIVES: The efficacy of our current approach to incorporating intracranial pressure (ICP) data into pediatric severe traumatic brain injury (sTBI) management is incompletely understood, lacking data from multicenter, prospective, randomized studies. The National Institutes of Health-supported Benchmark Evidence from Latin America-Treatment of Raised Intracranial Pressure-Pediatrics trial will compare outcomes from pediatric sTBI of a management protocol based on ICP monitoring vs 1 based on imaging and clinical examination without monitoring. Because no applicable comprehensive management algorithms for either cohort are available, it was necessary to develop them. METHODS: A consensus conference involving the 21 intensivists and neurosurgeons from the 8 trial sites used Delphi-based methodology to formulate management algorithms for both study cohorts. We included rec...
5
artículo
Publicado 2023
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BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) is a major global public health problem. It is a leading cause of death and disability in children and adolescents worldwide. Although increased intracranial pressure (ICP) is common and associated with death and poor outcome after pediatric TBI, the efficacy of current ICP-based management remains controversial. We intend to provide Class I evidence testing the efficacy of a protocol based on current ICP monitor-based management vs care based on imaging and clinical examination without ICP monitoring in pediatric severe TBI. METHODS: A phase III, multicenter, parallel-group, randomized superiority trial performed in intensive care units in Central and South America to determine the impact on 6-month outcome of children aged 1-12 years with severe TBI (age-Appropriate Glasgow Coma Scale score ?8) randomized to ICP-based or non-ICP-b...
6
artículo
Publicado 2024
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BACKGROUND AND OBJECTIVES: The efficacy of our current approach to incorporating intracranial pressure (ICP) data into pediatric severe traumatic brain injury (sTBI) management is incompletely understood, lacking data from multicenter, prospective, randomized studies. The National Institutes of Health-supported Benchmark Evidence from Latin America-Treatment of Raised Intracranial Pressure-Pediatrics trial will compare outcomes from pediatric sTBI of a management protocol based on ICP monitoring vs 1 based on imaging and clinical examination without monitoring. Because no applicable comprehensive management algorithms for either cohort are available, it was necessary to develop them. METHODS: A consensus conference involving the 21 intensivists and neurosurgeons from the 8 trial sites used Delphi-based methodology to formulate management algorithms for both study cohorts. We included rec...
