In order to determine the relationship between uric acid serum levels, hemoglobin and hematocrit in highlander native fellows; 40 blood samples of apparently healthy native fellows from Cerro de Pasco (4380 meters over sea level) were analyzed; and as reference, 25 samples of native fellows from Lima (150 m) were also analyzed, of both sexes and 34 year-old average. The results stated that there is a significant correlation between the levels of uric acid, hemoglobin and hematocrit, demonstrating that in high altitude the higher values of uric acid found would not be due to any pathology, but rather it is a normal present condition with high levels of hemoglobin and hematocrit which iscommon in highlander native fellows.

In order to determine the relationship between uric acid serum levels, hemoglobin and hematocrit in highlander native fellows; 40 blood samples of apparently healthy native fellows from Cerro de Pasco (4380 meters over sea level) were analyzed; and as reference, 25 samples of native fellows from Lima (150 m) were also analyzed, of both sexes and 34 year-old average. The results stated that there is a significant correlation between the levels of uric acid, hemoglobin and hematocrit, demonstrating that in high altitude the higher values of uric acid found would not be due to any pathology, but rather it is a normal present condition with high levels of hemoglobin and hematocrit which iscommon in highlander native fellows.

Heart rnitochondrion ATPase activity, ADP:O ratio (P:O) and Respiratory Control (RCR) are compared between guinea pigs from high altitude (Morococha, 4540 m) (HA) and those from sea level (SL). The study comprised 60 male guinea pigs, 30 from each altitude level, with mean weight 400-450 grams. Heart mitochondria were obtained by differential centrifugation at 4°C. P:O ratio and RCR were measured polarographically by Tyler method, and ATP hydrolysis was done by Holton et al. Method. Mean values obtained for heart mitochondria at SL and HA, expressed in mmoles oxygen uptake/mg protein/hour, were, with Glutamate + Malate as subtrates, respectiveIy: P:O 2.90, RCR 6.02 and P:O 2.93, RCR 6.0; and, with Pyruvate + Malate as subtrates, respectively P:O 2.60, RCR 5.0 and P:O 2.70, RCR 4.80. ATPase activity was at SL and HA, respectively: 57.50 and 64.50 mmoles P /mg protein/hour. The results su...

Heart rnitochondrion ATPase activity, ADP:O ratio (P:O) and Respiratory Control (RCR) are compared between guinea pigs from high altitude (Morococha, 4540 m) (HA) and those from sea level (SL). The study comprised 60 male guinea pigs, 30 from each altitude level, with mean weight 400-450 grams. Heart mitochondria were obtained by differential centrifugation at 4°C. P:O ratio and RCR were measured polarographically by Tyler method, and ATP hydrolysis was done by Holton et al. Method. Mean values obtained for heart mitochondria at SL and HA, expressed in mmoles oxygen uptake/mg protein/hour, were, with Glutamate + Malate as subtrates, respectiveIy: P:O 2.90, RCR 6.02 and P:O 2.93, RCR 6.0; and, with Pyruvate + Malate as subtrates, respectively P:O 2.60, RCR 5.0 and P:O 2.70, RCR 4.80. ATPase activity was at SL and HA, respectively: 57.50 and 64.50 mmoles P /mg protein/hour. The results su...