Infectious bursal disease is a pathology of viral origin that affects poultry, causing a high mortality rate. Existing vaccines face the problem of the appearance of new strains, so searches are made for molecules with potential binding affinity to viral proteins. Withania somnifera extract is involved in the replication of infectious bursitis virus, but the possible mechanism of action is not well understood. The aim of this study was to identify, through in silico methods, the phytoconstituents of W. somnifera with binding affinity to the active site of viral protein 1 (VP1) of infectious bursal disease virus. Molecular docking assays were performed between VP1 and 27 phytoconstituents described in W. somnifera. The binding energy data obtained were analysed with the Kruskal-Wallis test and Dunn’s test (p<0.05). The results showed that the compounds somniferin, withanolide A, with...