In this work the sensibility behavior of a coaxial GeHP detector is presented with respect to the arrival of a colhmated radiation beam in the frontal and lateral sides ofthe detector. The results show that for a horizontal or vertical configuration of the cryostat, a preferential direction of the detection exists. From the sensibility profiles, an estimate of the sensitive dimension of the semiconductor glass of the detector was obtained.

The effect of three levels of inclusion of cotton seed meal (PA) of low level of gossypol in the concentrate of 36 replacement Holstein calves was evaluated. Three treatments were used: T0: 0% PA; T1: 10% PA and T2: 20% PA with 0, 150 and 300 ppm of free gossypol respectively. The diets were supplied from birth to weaning (60 days). No significant differences were observed between treatments for feed consumption, body weight gain, final body weight or size. On the contrary, the activity of the serum sorbitol dehydrogenase enzyme was 29.5, 44.7 and 59.5 U/l for T0, T1 and T2, respectively (p<0.001), exceeding the value considered normal (14.7 ± 1.3 U/l); however, there were no visible negative effects on calves.

Se evaluó el efecto de tres niveles de inclusión de pasta de algodón (PA) de nivel bajo de gosipol en el concentrado de 36 terneras Holstein de reemplazo, Se trabajó con tres tratamientos: T0: 0% PA; T1: 10% PA y T2: 20% PA con 0, 150 y 300 ppm de gosipol libre, respectivamente. Las dietas fueron suministradas dese el nacimiento hasta el destete (60 días). No se observaron diferencias significativas entre tratamientos para consumo de alimento, ganancia de peso, peso vivo final ni altura a la cruz. Por el contrario, la actividad de la enzima sorbitol deshidrogenasa sérica fue de 29.5, 44.7 y 59.5 U/l para T0, T1 y T2, respectivamente (p<0.001), superando el valor considerado como normal (14.7 ± 1.3 U/l); no obstante, no hubo efectos negativos visibles en las terneras.

Vegetable profilins are considered potent allergens for their cross-reactivity as a result of the high sequence identity. Nowadays an attractive attention is focused to find new ligands to inhibit the active site of allergenic profilins. Some studies have shown that caffeic acid may have a certain inhibitory effect on some allergens. For this reason, we studied caffeic acid as an important ligand and its interaction between seven vegetable profilins. We applied molecular dynamic simulations methods and binding free energy analysis by MM–PBSA. We found that caffeic acid had a favorable behavior, and their coupling was mediated by hydrophobic interactions. Furthermore, the analysis of epitopes showed an important contribution of the secondary structure after docking simulations. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

Se prepararon carbones activados a partir de dos precursores de la actividad forestal utilizando activación química en un solopaso con ZnCl2. Las capacidades de adsorción se determinaron con azul de metileno en soluciones sintéticas y con metalespesados de agua de un río contaminado. Las áreas superficiales específicas de los carbones activados se calcularon entre 1278y 1404 m2/g. Una caracterización de los materiales se realizó mediante FTIR, espectroscopía RAMAN, difracción de rayos Xy microscopía electrónica de barrido. La estructura porosa de ambos carbones activados fue predominantemente microporosacon presencia de mesoporos. La máxima adsorción de azul de metileno por ambos carbones fue de entre 250 mg/g y 357 mg/g.La cinética de adsorción de azul de metileno con diferentes concentraciones iniciales del colorante y diferentes dosis de carbónactivado, también fue ...

Homodimeric KATII is an enzyme involved in l-kynurenine transamination to kynurenic acid. The increase in kynurenic acid concentration is predominant in schizophrenia and other disorders. Currently, the search for new KATII inhibitors continues to be a challenge. The aim of this work was to analyze the possible role of nicotine in KATII inhibition and compare it with the reversible inhibitor NS1502. We have used computational methods of quantum mechanics, docking, molecular dynamics, and binding energy (molecular mechanics/Poisson–Boltzmann surface area). The results of chemical reactivity showed that the nucleophilic and electrophilic attacks would be more significant in nicotine than in NS1502. The molecular dynamics simulations provided a molecular understanding of the binding interaction of nicotine and NS1502 with KATII. The nicotine binding energy was similar to that of the NS150...

The residual stresses and the molecular direction through a product provide the important information on how that product will behave. This is an important preoccupation in the production of plastics by the uses such as information storage. In this work a method of optional non-destructiva testing of evaluation of the quality of compact discs was evaluated and a quantitative analysis became of the state of different tension of CD's.

In this work it is presented the use of one solid state nuclear track detector, CR-39, for the determination of thermal neutron flux distribution from neutron sources, by means ofthe (n,p) nuclear reaction. Measurements of the thermal flux from an Am-Be neutron source with polyethylene and paraffin moderators were chemically etched in NaOH 6,25 N at 71 'C during 6 hours. An optical microscope 160X was used to observe the etched tracks. The flux profiles were obtained. 1t was found that polyethylene is a better moderator than paraffin for this neutron source.

The aim of this study was to determine the differences between three class intervals obtained from the levels of blood urea nitrogen (BUN) and the pregnancy rate in alpacas during the reproductive season. The study was conducted in a community cooperative in Cerro de Pasco, Peru at an altitude of 4318 m in February 2017. Fifty-two adult alpacas with more than two parturitions were evaluated. Blood samples were taken on the day of the single mount. BUN levels were determined using a commercial colorimetry kit and pregnancy was determined by ultrasonography 35 days post- mounting. The BUN levels varied between 15.07 and 46.88 mg/dl and the pregnancy rate was 59.6%. The pregnancy rate was associated with lower and higher levels of blood urea nitrogen.

The aim of this study was to know the levels of phosphorus and its effects on feed intake and body weight in female alpacas during the breeding season (January-February) and weaning (August-September). In the first phase, serum phosphorus levels were determined in 200 11-13-month-old alpacas, located in four alpaca regions of Peru. P levels were 8.25 ± 1.63, 5.25 ± 1.46, 6.42 ± 1.84 and 4.8 ± 1.61 mg/dl for the regions of Pasco, Junín, Cuzco and Puno, respectively, with significant differences (p<0.05) between regions. P values in one region were below the reference limit (5-11.5 mg/dl) and the another near the lower limit, which could be considered as deficient in P. In the second phase, a controlled experiment was carried out with three concentrations of P in the diet: 0.16% (T1), 0.25% (T2) and 0.34% (T3), using 16 weaned female alpacas per group (7-8 months, 25.25 ± 1.62 kg)...

El objetivo del estudio fue determinar las diferencias entre tres intervalos de clase obtenidos a partir de los niveles de nitrógeno ureico sanguíneo (NUS) y la tasa de preñez en alpacas durante la estación reproductiva. El estudio se realizó en una cooperativa comunal de Cerro de Pasco, Perú a una altitud de 4318 msnm en febrero de 2017. Se evaluaron 52 alpacas adultas con más de dos partos. Las muestras de sangre se tomaron en el día de la monta única. Los niveles de NUS se determinaron mediante un kit comercial por colorimetría y la preñez fue determinada mediante ultrasonografía a los 35 días de la monta. Los niveles de NUS variaron entre 15.07 y 46.88 mg/dl y la tasa de preñez fue de 59.6%. La tasa de preñez estuvo asociada a los niveles más bajos y más altos de nitrógeno ureico sanguíneo.

The aim of this study was to know the levels of phosphorus and its effects on feed intake and body weight in female alpacas during the breeding season (January-February) and weaning (August-September). In the first phase, serum phosphorus levels were determined in 200 11-13-month-old alpacas, located in four alpaca regions of Peru. P levels were 8.25 ± 1.63, 5.25 ± 1.46, 6.42 ± 1.84 and 4.8 ± 1.61 mg/dl for the regions of Pasco, Junín, Cuzco and Puno, respectively, with significant differences (p<0.05) between regions. P values in one region were below the reference limit (5-11.5 mg/dl) and the another near the lower limit, which could be considered as deficient in P. In the second phase, a controlled experiment was carried out with three concentrations of P in the diet: 0.16% (T1), 0.25% (T2) and 0.34% (T3), using 16 weaned female alpacas per group (7-8 months, 25.25 ± 1.62 kg)...

The residual stresses and the molecular direction through a product provide the important information on how that product will behave. This is an important preoccupation in the production of plastics by the uses such as information storage. In this work a method of optional non-destructiva testing of evaluation of the quality of compact discs was evaluated and a quantitative analysis became of the state of different tension of CD's.

Profilins are panallergenic proteins of clinical relevance. We compared three groups of three-dimensional structures from six vegetable profilins. The first group was composed of crystal structures obtained by X-ray diffraction. The second and the third group structures were obtained by homology modeling; the selection criteria of the templates for these were based on the best resolution structure and the highest sequence identity, respectively. All of the structures underwent a 200 ns molecular dynamics simulation. The best template for the second group was Art v 4 and for the third group was the crystal structure corresponding to each profilin, except for Zea m 12. After molecular dynamics simulation, root-mean-square deviation, root-mean-square fluctuation, and radii of gyration values were similar in all groups, except for Amb a 8 (second group) and Zea m 12 (third group). All struct...

PF04859989 is a potential novel drug designed to attenuate symptoms of Schizophrenia. We analyzed the substitution effect on PF04859989 using three functional, which included the long-range correction. The substituents were both donor and attractor electrons, in two positions of the fused-ring molecule, in positions six and seven. Global reactivity indices were analyzed, finding that it does not present more information except electrophilicity, when analyzed with respect to the Hammet parameter, representing a quadratic correlation closer to the unit. The hydrophobic capacity (cLogP) was considered, finding that the groups such as CH3, CN, Cl and COCH3 increase hydrophobic capacity both in substitution in position six and seven. Additionally, we found that isomers conformations in position three of the amino group marked that equatorial isomers are more stable than the axial ones.

The aggregation of proteins in the brain is one of the main features of neurodegenerative diseases. In Alzheimer’s disease, the abnormal aggregation of A?-42 is due to intrinsic and extrinsic factors. The latter is due to variations in the environment, such as temperature, salt concentration, and pH. We evaluated the effect of protonation/deprotonation of residues that are part of trimeric and pentameric oligomers at pH 5, pH 6, and pH 7. Molecular dynamics simulation at 200 ns in the canonical ensemble was implemented. The results have revealed that histidine, glutamic acid, and aspartic acid residues showed a protonation/deprotonation effect in oligomers. The root mean square deviation analysis was used to analyze the structural stability at different pHs. We found an increase in hydrophobicity in the side chains of the trimer, while in the pentamer, the structural instability of a c...

The residual tension and the molecular orientation in a material provide important information about its behavior. The presence or absence of residual tension determines the quality of the plastics used for the storage of information and others. In this work, a non destructive method was implemented for the evaluation of compact disks, as well as the storage of information in the same ones by means optic analysis of residual tension. A quantitative analysis of the tension state in different marks of CD was also made.

The present study, of descriptive nature, non experimental and cross-sectional, describes the dimensions of personality, intelligence, motivation and also learning strategies in 553 students of the CEPRE-UNMSM using Eynseck Personality Inventory Form B, D-70 Test and MSLQ-SF Questionnaire. The results indicate that the freshmen 2013 San Marcos tend to sanguine, because the G factor of intelligence places them in the top category, they have moderate anxiety and use, to learn, mostly using cognitive and metacognitive strategy development in resource management strategy better manage self-regulation effort and value components are intrinsically oriented to your goals. The purpose is to identify the psychological profile of the students, this allows the formulation of programs to orientate and/or reorientate the academic tasks of pre-university students.

The present study, of descriptive nature, non experimental and cross-sectional, describes the dimensions of personality, intelligence, motivation and also learning strategies in 553 students of the CEPRE-UNMSM using Eynseck Personality Inventory Form B, D-70 Test and MSLQ-SF Questionnaire. The results indicate that the freshmen 2013 San Marcos tend to sanguine, because the G factor of intelligence places them in the top category, they have moderate anxiety and use, to learn, mostly using cognitive and metacognitive strategy development in resource management strategy better manage self-regulation effort and value components are intrinsically oriented to your goals. The purpose is to identify the psychological profile of the students, this allows the formulation of programs to orientate and/or reorientate the academic tasks of pre-university students.