Objetivo: El objetivo general de este estudio fue determinar la frecuencia de la sobreexpresión de Cerb-b2 en el cáncer de mama infiltrante diagnosticado en el servicio de anatomía patológica del hospital regional Lambayeque durante los años de 2013-1016. Materiales y métodos: Se estudiaron retrospectiva y prospectivamente 176 casos con cáncer (carcinoma) de mama infiltrante diagnosticadas mediante biopsia ―trucut‖ o core, biopsia insicional, mastectomía o tumorectomia a los cuales se les realizó inmunohistoquimica para evaluar la sobreexpresión de cerb-b2 (Her2/neu). Resultados: Se encontró sobreexpresión positiva de cerbb2 (3+) en 85 casos que representan el 48.3% y sobreexpresión dudosa (2+) en 65 pacientes (36.9%) y fue negativo (0+ y 1+) en 26 casos. Esta sobreexpresión de cerbb2 es más alta de lo que menciona la literatura. También hay que considerar la sobreexp...

The neurofibroma of the bile duct is an extremely rare and generally asymptomatic disease, however, it maybe cause obstructive jaundice and mimic a Klatskin tumor, leading to radical surgical treatment and increased patient morbidity. We present the case of a 62-year-old woman who underwent cholecystectomy 10 years ago, with jaundice and pain in the right upper quadrant, as well as auxiliary tests compatible with cholestasis. Dilation of the bile duct and the presence of a tumor in the left hepatic duct were observed by magnetic cholangioresonance. The preoperative clinical diagnosis was hilar cholangiocarcinoma, but the histopathological study revealed a neoplasm composed of spindle cells without atypia or mitotic activity, whose neurogenic lineage supported by its positivity to protein S100 in immunohistochemistry. We report the case given its infrequency in the literature and i...

Background: Primary gastric lymphomas account for less than 5% of non-Hodgkin lymphomas (NHL). The vast majority of primary gastric lymphomas are high-grade B-cell lymphomas. Primary gastric T-cell lymphomas are very rare and are usually associated with HTLV-1 infection in endemic regions. Material and methods. We describe the case of a middle-aged female patient who presented with pneumoperitoneum due to a perforated gastric ulcer, wasting syndrome, and skin and oral lesions. Results. Histopathology and immunohistochemistry confirmed primary gastric T-cell lymphoma with skin involvement. The serology for HTLV-1, Epstein-Barr virus and HIV were negative. Conclusion. The aim of this report is to present this extremely rare presentation of primary gastric lymphoma.