Objective: To select native microorganisms with the ability to degrade non-steroidal anti-inflammatory drugs (Naproxen, Paracetamol, Ibuprofen and Diclofenac) and psychotropic drugs (Carbamazepine, Alprazolam and Clonazepam) from wastewater. Material and Methods: This study examines the degradation of microorganisms in wastewater against anti-inflammatory and psychotropic drugs in Lima. Samples were collected, diluted and plated. After colony verification, degradation capacity was assessed by measuring turbidity and absorbance at 600 nm in a spectrophotometer. Results: Bacterial colonies were analyzed, highlighting characteristics such as white color, circular shape, entire edge, smooth texture, medium size and predominance of gram-positive bacteria. Anti-inflammatory and psychotropic drugs were evaluated, and specific responses of microorganisms were observed. Turbidity in the tubes ind...