Lymphocyte-to-Monocyte ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and clinical outcomes for cholangiocarcinoma patients. A systematic review and meta-analysis were performed to assess the association between LMR values and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used Hazard ratio (HR) and their 95% confidence interval (CI) as a measure of effect for the random effect model meta-analysis. The Newcastle–Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. A total of 19 studies were included in this study (n = 3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were assoc...

Antecedentes y objetivos: La relación de linfocitos a monocitos (LMR) ha demostrado una asociación con los resultados de supervivencia en varias enfermedades oncológicas. Este estudio tuvo como objetivo evaluar la asociación entre LMR y los resultados clínicos para pacientes con colangiocarcinoma. Material y métodos: Se realizó una revisión sistemática y un metaanálisis para evaluar la asociación entre los valores de LMR y la supervivencia general (SG), la supervivencia libre de enfermedad (DFS), la supervivencia libre de recurrencia (RFS) y el tiempo hasta la recurrencia (TTR) en pacientes con colangiocarcinoma. Utilizamos el cociente de riesgos (HR) y el intervalo de confianza (IC) del 95 % como medida del efecto para el metaanálisis del modelo de efectos aleatorios. Se utilizó la escala de Newcastle-Ottawa para la evaluación de la calidad. La prueba de Egger y el gráfic...

Background: The pathophysiology of polycystic ovary syndrome (PCOS) is complex and heterogeneous. This systematic review and meta-analysis aimed to determine the triglyceride–glucose index and lipid ratios in women with and without PCOS. Methods: Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride–glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs). Results: The search identified 61 observational studies, including case–control (n = 37), cohort (n = 2), and cross-sectional (n = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared...