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artículo

Clinicopathological Features and Mortality in Patients With Kaposi Sarcoma and HIV: A Retrospective Analysis of a Thirty-Year Study From a Peruvian Oncologic Center

Publicado por
Cuellar, LE, Meza, K, Holguín, AM, Velarde, J, Portillo-Alvarez, D, Castro-Oliden, V, Sulca-Huamani, O, Intimayta-Escalante C,, Gaby-Pérez R,, Patel A,

Publicado 2022

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Purpose: Kaposi's sarcoma (KS) is a multifocal angioproliferative disease. In Peru, the implementation of the highly active antiretroviral treatment (HAART) program was in 2005, the model for treating patients with HIV-positive KS shifted to a potential cure. In this study, we aim to compare clinicopathological characteristics and prognostic factors associated with outcomes in patients with HIV-positive KS. Methods: We developed a retrospective cohort study that includes patients with HIV/AIDS and KS seen in the Instituto Nacional de Enfermedades Neoplasicas between 1987 and 2017. Patients were divided into two groups according to the implementation of HAART in our country: the non-HAART group and those treated with HAART after 2005. Multivariate analysis for overall survival (OS) was performed with the Cox proportional hazard regression model. Results: There was a greater visceral compr...

artículo

Epidemiology, clinical aspects, outcomes and prognostic factors associated with Trichosporon fungaemia: results of an international multicentre study carried out at 23 medical cent...

Publicado por
Nobrega de Almeida, J, Francisco, EC, Holguín Ruiz, A, Cuéllar, LE, Rodrigues Aquino, V, Verena Mendes, A, Queiroz-Telles, F, Santos, DW, Guimarães, T, Maranhão Chaves, G, Grassi de Miranda, B, Araújo Motta, F, Vargas Schwarzbold, A, Oliveira, M, Riera, F, Sardi Perozin, J, Pereira Neves, R, França, E, Silva, ILA, Sztajnbok, J, Fernandes Ramos, J, Borges Botura, M, Carlesse, F, de Tarso de, O E, Castro, P, Nyirenda, T, Colombo, AL

Publicado 2021

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Background: Trichosporon fungaemia (TF) episodes have increased in recent years and mortality rates remain high despite the advances in the management of sepsis. New concepts about its clinical course, treatment and microbiology need to be investigated for the better management of this infection. Objectives: To describe the aetiology, natural history, clinical management and prognostic factors of TF. Methods: TF episodes documented between 2005 and 2018 in 23 South American centres were retrospectively investigated by using a standard clinical form. Molecular identification, antifungal susceptibility testing and biofilm production were also performed. Results: Eighty-eight TF episodes were studied. Patients had several underlying conditions, including haematological diseases (47.7%), post-operative status (34%), solid organ transplants (n = 7, 7.9%), among others. Seventy-three (82.9%) p...