Three donkeys (Equus asinus Linnaeus, 1758), two males and a female sex, between 5-8 years of old, inathletic shape, in Choroni, Aragua, Venezuela were examined. Clinical examination evidenced hirsute hair and moderate body condition. Nodular dermatitis like skin lesions showed crusted erythematous to chronic ulcerated center with edges of reepithelialization complicated. Tissue sections were taken from skin in affected area described above, by excision biopsy technique. The samples were fixed in 10% formalin and processed by conventional histological processing and stained with hematoxylin and eosin. Additional special stains used included PAS, Giemsa and Grocott. The histological section showed nodular erosive ulcerative crusting dermatitis. Perivascular dermatitis type I and inflammatory infiltrate were observed. Mononuclear lymphocytes and polymorphonuclear neutrophilic plasmocytorio...