To determine the relationship between dental caries disease and the level of knowledge about oral health of parents with children from 36 to 71 months of age. The methodological design was observational, descriptive, cross-sectional, and correlational, and the sample consisted of 123 children enrolled in the IEI N ° 161 "Carapongo" during the year 2018. A validated questionnaire addressed to the parents was carried out, children were evaluated clinically using the ceo-d index, the data were analyzed statistically and for the possible correlation of the variables the Spearman correlation coefficient statistical test was used. A prevalence of dental caries of 89.43% was found for children between 36 and 71 months, (X= 4.03, SD= 2.820) which indicates a moderate level of severity, where children aged 60-71 months obtained a higher ceo-d index. (X= 4.18, SD= 3.16) with respect to the other ...