Actualmente las obras de infraestructura pública, ejecutadas por contrata en el Perú, no poseen una gestión clara de la calidad con que se deba ejecutar. Esta gestión debe iniciar en la planeación e integrar los procesos constructivos. Actualmente el control se basa en el resultado final de ensayos realizados, cuando, en algunas veces ya es demasiado tarde realizar mejoras, esto generalmente ocurre en empresas donde se desarrolla la micro y pequeña empresa. Este trabajo de investigación mostrará cómo mejorar la ejecución de las partidas de concreto armado en obras de infraestructura educativa u obras similares, a través de planteamientos en la planificación como en la ejecución de dichas partidas. Las propuestas planteadas servirán como complemento y mejora de las normativas existentes en el Reglamento Nacional de Edificaciones. Para la obtención de información actualizad...

In this research project, the evaluation of the accessibility and mobility difficulties faced by people with disabilities when circulating around a vehicular intersection is addressed. To carry out this evaluation, the Vissim and SSAM programs were used. The assessment of conflicts is carried out through the analysis of heat maps obtained with SSAM. In the context of this article, an analysis is carried out of the number of conflicts between vehicles on a road segment that is part of a traffic signalized intersection, characterized by the constant presence of congestion. Along this stretch, a decrease in lanes, variability in lane widths and lack of uniformity are observed, generating a point of congestion that gives rise to various types of vehicular conflicts. To carry out this evaluation, the micro simulation software VISSIM 8.0 was used, which models the real situation of the interse...

“Abstract Background and Aims: Low‐risk human papillomaviruses (HPV) are important in pregnant women because they are risk factors for Condyloma acuminatum and recurrent respiratory papillomatosis in the newborn. On the other hand, HPV may contribute to the development of preneoplastic lesions such as LSIL in pregnant women. We aimed to assess the frequency of HPV infections in low‐grade squamous intraepithelial lesion (LSIL) in Peruvian pregnant women. Methods: A cross‐sectional study was conducted from 2011 to 2015 in 84 primiparous‐ and multiparous pregnant women (mean age: 27 ± 6.3 years). Pregnant women of 18–45 years attending gynecology outpatient department were included for the study. LSIL and HPV (nuclear irregularities, koilocytosis, and cytopathic effect) cellular alterations were reported using the Bethesda System guidelines. Results: Sixty‐four percent had cy...

“Abstract Background and Aims: Low‐risk human papillomaviruses (HPV) are important in pregnant women because they are risk factors for Condyloma acuminatum and recurrent respiratory papillomatosis in the newborn. On the other hand, HPV may contribute to the development of preneoplastic lesions such as LSIL in pregnant women. We aimed to assess the frequency of HPV infections in low‐grade squamous intraepithelial lesion (LSIL) in Peruvian pregnant women. Methods: A cross‐sectional study was conducted from 2011 to 2015 in 84 primiparous‐ and multiparous pregnant women (mean age: 27 ± 6.3 years). Pregnant women of 18–45 years attending gynecology outpatient department were included for the study. LSIL and HPV (nuclear irregularities, koilocytosis, and cytopathic effect) cellular alterations were reported using the Bethesda System guidelines. Results: Sixty‐four percent had cy...

Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer with limited options of targeted therapy. Recent findings suggest that the clinical course of TNBC may be modified by the presence of tumor-infiltrating lymphocytes (TILs) and chemokine's expression, such as CCL5. Diverse studies have shown that CCL5 suppresses anti-tumor immunity and it has been related to poor outcome in different types of cancer while in other studies, this gene has been related with a better outcome. We sought to determine the association of CCL5 with the recruitment of TILs and other immune cells. With this aim we evaluated a retrospective cohort of 72 TNBC patients as well as publicly available datasets. TILs were correlated with residual tumor size after neoadjuvant chemotherapy (NAC) and CCL5 expression. In univariate analysis, TILs and CCL5 were both associated to the distant recur...

Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. Latin America (LATAM) is a region characterised by fragmented healthcare, high rates of poverty and disparities to access to a basic standard of care not only for cancer but also for other complex diseases. Patients from the public setting cannot afford targeted therapy, the facilities offering genomic platforms are scarce and the use of high-precision radiotherapy is limited to few facilities. Despite the fact that LATAM oncologists are well-trained in the use of genomic platforms and constantly participate in genomic projects, a medical practice based in precision oncology is a great challeng...