Based on a bibliographic review of the literature, a consensus of international experts has been carried out on the use of vitamins B1, B6, B12, in their deficiencies, and in the peripheral neuropathy that may be associated with them, to optimize the management of these conditions. Several questions considered important and worthy of being addressed and clarified were raised, retaining nine of them for further discussion to achieve consensus. Forty one recommendations on the management of these conditions have been proposed, with unanimity of the participants in the consensus. This has been an attempt to clarify controversial points, assisting the clinician's attitude in current medical practice.

The term peripheral neuropathy includes very varied and complex conditions that present difficulties in their diagnostic and therapeutic approach. One of the factors underlying these entities is the deficiency of neurotrophic vitamins B1, B6 and B12. Given the uncertainity and poorly known extremes of this subject and the empirical approach when using the therapeutic resources, a systematic search of the literature has been carried out trying to organize and base on scientific evidence the ideas and conflicting points that have presided over the approach to the issue by the professionals concerned by it. This study serves as the basis for an attempt at expert consensus that promotes a series of recommendations that rationalize and facilitate the management of the issue in clinical practice.