Objective: to determine the concordance between panoramic radiography and cone beam computed tomography in analysis of the relationship of mandibular third molars with inferior dental canal in patients attended in a peruvian population. Material and methods: this research was observational, descriptive, cross-sectional and retrospective. The sample was 112 mandibular third molars and modified classification of Robert Langlais was used for radiographic evaluation. Likewise, other variables were age, sex and side. The statistical tests used were chi square, Mann Whitney U test, Kruskall Wallis test and Cohen's kappa coefficient. Results: according to panoramic radiography, 82.1% (n = 92) of third molars showed superposition, of which the highest percentage was for “interruption of white line” with 25.9% (n = 29). According to cone beam computed tomography, 65.2% (n = 73) of the molars ...