Objective: To determine the association between depression, anxiety, and stress according to sociodemographic and occupational factors in Peruvian health professionals during the coronavirus disease 2019 (COVID-19) pandemic. Methods: Cross-sectional analytical and multicentre study, based on a virtual survey sent to Peruvian health personnel (from the 25 Peruvian regions) working during the COVID-19 pandemic. The three dependent variables (depression, anxiety, and stress) were measured with the Depression, Anxiety, and Stress Scale -21 (DASS-21) (Cronbach’s Alpha: 0.93) and compared with sociodemographic and occupational variables. P-values were obtained through generalized linear models, adjusted for each location where the survey was sent. Results: Of the 550 participants, 2%, 13%, and 3% of them had severe or very severe depression, anxiety, and stress, respectively. In the multivar...