Creutzfeldt-Jakob disease (CJD) is the commonest human prion disease with a reported annual incidence rate of one per million worldwide. CJD has a bad prognosis, and the mean length of survival is 4-6 months. Only 11 cases have been reported in the literature from Perú. Thus, we report a case of a 66-year-old male patient with the diagnosis of probable sporadic CJD in whom the survival duration was of 25 months. We identify that the time from disease onset to myoclonus and to reach the akinetic mutism state, the absence of early imaging findings, the delayed cortical and basal ganglia involvement and the supportive therapies implemented were factors that could contribute for the long survival in this patient. 

A 40-year-old man, with a history of migraine, experienced a left occipital headache, tinnitus and photopsias. He was treated with analgesics at the emergency room with partial relief during 3 consecutive visits during the week prior to admission. At admission, general physical exam was normal as was the neurological examination. A lumbar puncture (LP) was performed, showing no blood cells but 100 mononuclear cells with normal protein and glucose levels. Cerebrospinal fluid (CSF) microbiological and virologic tests and brain imaging studies were not contributory. The pain was controlled after a trigeminal nerve block. Five days after admission and with the status migrainosus resolved, a second LP was performed which was reported as normal with resolution of the pleocytosis. Recognition of transitory CSF pleocytosis in the context of an acute migraine episode could serve to avoid unnecess...

Introducción: La Epilepsia es un desorden neurológico relativamente frecuente. No disponiendo de literatura nacional y considerando la alta prevalencia en nuestro medio y el hecho de disponer de tecnología para verificar las causas, decidimos investigar la relación entre trastornos de Migración Neuronal Epilepsia y factores de riesgo en una población hospitalaria. Material y métodos: Se realizó un estudio prospectivo, descriptivo, serie de casos, de enero a diciembre de 1999 en el Hospital Nacional Cayetano Heredia. Se revisaron las historias clínicas de pacientes con epilepsia, con y sin TMN, que acudieron como pacientes nuevos. Se realizó una encuesta a las madres de estos pacientes. Luego de conocidas las etiologías, se separaron las muestras. El cuestionario incluyó detalles del embarazo en relación a exposición a medicinas, tóxicos, radiaciones o traumas, parto y comp...