Carbon dioxide (CO2), is found in nature in a gaseous state. It is a colorless, odorless, and is a key part of the carbon cycle, its concentration in the air is 0.03%. CO2 is one of the basic components in the homeostasis of human body and is a result of cellular metabolism. CO2 is 20 times more soluble in water than in air and according to many scientific studies do not leading to no clinically significant embolism. In the blood circulation the carbon dioxide is transported to the lungs by three routes: 65% as bicarbonate ion, 25% as Co2 bound to proteins, especially the hemoglobin and plasma CO2 dissolved in 10%. [1]. In European countries like France and Germany, from the Middle Ages, are known the healing properties of carbon dioxide on circulation problems and skin, and since 1920 has been applied subcutaneous CO2 for medical treatment [2]. Current studies demonstrate the effect of ...

Carboxytherapy is a medical technique that utilizes carbon dioxide for therapeutic purposes. The aim of this review was to assess the scientific evidence on the effects of carboxytherapy on metabolic health. The applications of carboxytherapy span various fields of medicine. Evidence shows that carbon dioxide is not only a key regulator of blood pH but also modulates gene expression, growth factors, and stimulates the production of endothelial progenitor cells. These effects are reflected in increased microcirculation in the skin (where collagen production is stimulated), in subcutaneous adipose tissue (where lipolysis and tissue reduction have been observed), in muscle (where it promotes mitochondrial biogenesis and muscle fiber differentiation), and in bone (where it stimulates repair). The activation of microcirculation is mediated by the upregulation of vascular endothelial growth fa...

Carboxytherapy is a medical technique that utilizes carbon dioxide for therapeutic purposes. The aim of this review was to assess the scientific evidence on the effects of carboxytherapy on metabolic health. The applications of carboxytherapy span various fields of medicine. Evidence shows that carbon dioxide is not only a key regulator of blood pH but also modulates gene expression, growth factors, and stimulates the production of endothelial progenitor cells. These effects are reflected in increased microcirculation in the skin (where collagen production is stimulated), in subcutaneous adipose tissue (where lipolysis and tissue reduction have been observed), in muscle (where it promotes mitochondrial biogenesis and muscle fiber differentiation), and in bone (where it stimulates repair). The activation of microcirculation is mediated by the upregulation of vascular endothelial growth fa...