Canine rabies is a current health problem, very important for public health, livestock production, and the economy. The objective of this research was to evaluate the Spatio-temporal distribution of canine rabies in the period 2009-2018 in Havana, Cuba. A descriptive, retrospective, passive, cross-sectional, observational study was conducted. For the statistical analysis, the Epidat software, version 3.1, based on a Microsoft Excel matrix, was used. The epidemiological indicators were determined: prevalence of cases, monthly time series, and cumulative trend of outbreaks. While, for the spatial analysis, the geographic coordinates were calculated from the centroid of each municipality. For visualization, the QGIS version 3.0.1 program and the GEOCUBA cartographic bases were used. The comparison of proportions was made for the positive cases between the peripheral and central areas, which...