The administration of human chorionic hormone and estrogen to normal rats, produces an atypical endometrial characterized histological simultaneous presence of proliferative and secretory changes. The core of epithelial cells shows that overall a more normal appearance and occasionally reaching vesicular large. Abnormal box can not be induced by treating rats with normal or chorionic estróqenos administered alone or both hormones to castrated animals. A similar alteration is, however; when ovariectomized rats are treated with large doses of estrogen and progesterone. Pathogenesis and the possible relationship of this alteration certain endometrial changes seen in humans is briefly discussed.

In 1954 we made the description and characterization of endometrial epithelial one alteration that occurs in some cases of chorionic, mola hidcrtidiforme, destruens chorioadenoma, cervical ectopic pregnancy and abortion. The alteration is characterized mainly by a nuclear hypertrophy with enlargement to a lesser degree in the cytoplasm and loss trend cell polarization. The affected glands may be secretory or proliferative, or show a pathological secretory and proliferative activity simultaneously. The cover may show epithelial injury. The alteration occurs focally compromising all or part of a gland or glands groups. Rarely is more or less diffuse. It may or not be decidual reaction.

The morphological characteristics of atypical epithelial disruption occurs in the seminal vesicle are described. The lesion is mainly characterized by focal areas in which there is marked nuclear hypertrophy and some degree of epithelial hyperplasia. The exioliadas hypertrophic cells can be confused with neoplastic cells. The alteration occurs mostly after the fourth decade. Inflammation and vascular sclerosis in the seminal vesicle, prostate gland hyperplasia, abnormality or atrophy of the testes, or pathological processes in each case apparently unrelated to the presence of the disturbance.

The histological features of atypical endometrial alterations we found in cases of uterine abortion, ectopic pregnancy, 44 cases described, hydatidiform mole, choriocarcinoma, destruens chorioadenoma, syncytial endometritis and normal uterine pregnancy, based on the study of 250 cases of uterine abortion, ectopic pregnancy, 32 cases of hydatidiform mole, 25 cases of chorionic, 6 cases of syncytial endometritis and 3 cases of apparently normal pregnancy.

Histological epidemiological experience, clinical, colposcopic, cytologic and has a solid foundation to the concept of cervical intraepithelial neoplastic disease. The various forms of dysplasia, carcinoma in situ and microinvasive carcinoma are thus initial understood as invasive evolving forms of the same biological process whose ultimate expression is the invasive carcinoma. With the appointment today of dysplasia qualify all atypical proliferations epidermoideas prior to cervical carcinoma in-situ. Cervical intraepithelial neoplastic disease is characterized by periods evolve regression and reoccurrence. The mild and moderate forms of dysplasia regressed more frequently than in-situ forms of severe dysplasia and carcinoma, rarely do. The origin of cervical neoplastic disease can be level or endocervix ectocervix. Most often it starts in the vicinity of the squamocolumnar area. A mino...

The histological features of endometrial atypical alteration we have found in cases of uterine abortion, extópico pregnancy decribe, hydatidiform mole, choriocarcinoma, destruens chorioadenoma, syncytial endometry and normal uterine pregnancy, based on the study of 250 cases of uterine abortion, 44 cases of extópico pregnancy, 32 cases of hydatidiform mole, 25 cases of coriopitelioma, 6 cases of syncytial endometritis and 3 cases of apparently normal pregnancy.

Objective: To compare Ayre spatula and cytobrush methods in uterine cervix premalignant and malignant lesions detection. Material and Methods: Endocervical smears taken from 140 patients with the Ayre spatula and cytobrush methods were extended on separate codified slides and examined by two different pathologists unaware of the smear collection method. Bethesda system was used for diagnosis. Results: Sixty-five versus thirty-five per cent of the samples had endocervical cells respectively obtained with the cytobrush and the Ayre spatula method. When analyzing the quantity of endocervical cells, the samples obtained with the cytobrush method had more than five clusters of endocervical cells (71,4%) than with the Ayre spatula method (36,4%). Conclusion: Cytobrush method seems to be more efficient than Ayre spatula method for obtaining endocervical cells.

The administration of human chorionic hormone, and estrogen, to normal rats, produces an atypical endometrial histological picture, characterized by simultaneous presence of secretory and proliferative changes. The core of epithelial cells shows that overall a more normal appearance and occasionally reaching vesicular large. Abnormal box can not be induced by treating rats with normal estrogen or chorionic administered alone or neutered animals both hormones. A similar alteration, however, is when ovariectomized rats are treated with large doses of estrogen and progesterone. The pathogenesis and the relationship of this condition with certain endometrial changes observed in humans briefly discussed.

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548 p.

Hace 25 años la Sociedad Peruana de Anatomía Patológica y el capítulo de Anatomía Patológica de la Sociedad Peruana de Patología, en gesto de madurez y solidaridad, acordaron fusionarse para constituir la Asociación Peruana de Patólogos. Quienes éramos miembros de las anteriores instituciones y participamos de ese esfuerzo somos, a su vez protagonistas de lo que ha ocurrido en el campo de la Patología en las cuatro últimas décadas. Período en el que en el marco mundial hemos vivido tantas innovaciones y en el nacional tantas expectativas y frustraciones, que justifican la iniciativa de la actual directiva de nuestra Asociación de intentar alguna forma de balance.

La historia de la Anatomía Patológica en el Perú ha seguido los grandes jalones que han caracterizado la evolución de esta especialidad en los países de Iberoamérica: inicio en las escuelas francesas y alemanas, con acento tanatológico, y transición gradual a la escuela americana, con acento experimental, clínico y quirúrgico, para desembocar, en el presente, en la vorágine tecnológica y biomolécular.

La historia de la Anatomía Patológica en el Perú ha seguido los grandes jalones que han caracterizado la evolución de esta especialidad en los países de Iberoamérica: inicio en las escuelas francesas y alemanas, con acento tanatológico, y transición gradual a la escuela americana, con acento experimental, clínico y quirúrgico, para desembocar, en el presente, en la vorágine tecnológica y biomolecular.

Pedro Weiss Harvey, como los grandes hombres de todos los tiempos en el Perú, contribuyó de una manera relevante en las áreas específicas que había constituído su fundamental quehacer, y llegado a la madurez, en el otoño e invierno de su vida, alcanzó el perfil del filósofo.

El examen de Papanicolaou es la más efectiva prueba de detección de cáncer en la historia de la medicina.Siendo lo anterior cierto, resulta interesante comprobar que, en años recientes, en los Estados Unidos de América, el “Pap test” – la forma abreviada coloquial como se denomina el examen – ha sido “bombardeado y sitiado por los medios de prensa”.El artículo de Wall Street Journal de Noviembre de 1987, y el escándalo suscitado en New Port, Rhode Island en 1993, que subrayan ejemplos de errores cometidos, han sido ampliamente comentado, creando una injustificada sensación de inseguridad y dando origen a una “explosión de litigios”.

Cada vez más leemos o escuchamos hablar sobre las células designadas en el idioma inglés como “stem cells”.¿Porqué esta actualidad?.

The most recent and astonishing scientific advances have allowed the development of fertilization techniques based on the somatic cell nuclear transfer method. Thanks to this, it has been possible to widen knowledge about embryo cells, maintaining their pluripotentiality and now there are some cell banks available for therapeutic purposes.However, embryo cell manipulation has been the subject of many discussion from the scientific, ethics, and politics point of view, because of many fears generated by the likelihood of manipulating the genetic machinery of a non-differentiated totipotent stem cell.In the last Presidential Elections in the USA, Mr. Barack Obama proimised to strengthen research in this promising field. This promise opens the way for many patients that are awaiing for therapy options that nowadays still are not possible.

Histological epidemiological experience, clinical, colposcopic, cytologic and has a solid foundation to the concept of cervical intraepithelial neoplastic disease. The various forms of dysplasia, carcinoma in situ and microinvasive carcinoma are thus initial understood as invasive evolving forms of the same biological process whose ultimate expression is the invasive carcinoma. With the appointment today of dysplasia qualify all atypical proliferations epidermoideas prior to cervical carcinoma in-situ. Cervical intraepithelial neoplastic disease is characterized by periods evolve regression and reoccurrence. The mild and moderate forms of dysplasia regressed more frequently than in-situ forms of severe dysplasia and carcinoma, rarely do. The origin of cervical neoplastic disease can be level or endocervix ectocervix. Most often it starts in the vicinity of the squamocolumnar area. A mino...

The administration of human chorionic hormone, and estrogen, to normal rats, produces an atypical endometrial histological picture, characterized by simultaneous presence of secretory and proliferative changes. The core of epithelial cells shows that overall a more normal appearance and occasionally reaching vesicular large. Abnormal box can not be induced by treating rats with normal estrogen or chorionic administered alone or neutered animals both hormones. A similar alteration, however, is when ovariectomized rats are treated with large doses of estrogen and progesterone. The pathogenesis and the relationship of this condition with certain endometrial changes observed in humans briefly discussed.

The histological features of endometrial atypical alteration we have found in cases of uterine abortion, extópico pregnancy decribe, hydatidiform mole, choriocarcinoma, destruens chorioadenoma, syncytial endometry and normal uterine pregnancy, based on the study of 250 cases of uterine abortion, 44 cases of extópico pregnancy, 32 cases of hydatidiform mole, 25 cases of coriopitelioma, 6 cases of syncytial endometritis and 3 cases of apparently normal pregnancy.