Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes

Descripción del Articulo

Artículo sustentado el 30 de Enero 2014 para la obtención del título profesional Médico Cirujano en la Escuela de Medicina, Facultad de Ciencias de la Salud. Universidad Peruana de Ciencias Aplicadas - UPC.
Detalles Bibliográficos
Autores: Weilg Espejo, Pablo, Orellana Peralta, Fiorella, Cornejo Pacheres, Hernán, Del Valle, Luis J., Cornejo Tapia, Ángela, Bazán Mayra, Jorge, Ruiz, Joaquim, Del Valle Mendoza, Juana
Formato: artículo
Fecha de Publicación:2014
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/313901
Enlace del recurso:http://hdl.handle.net/10757/313901
Nivel de acceso:acceso abierto
Materia:Viral genotypes
Epidemiology
Acute gastroenteritis
Peru
id UUPC_f812e28edebd7f591134db1f06817481
oai_identifier_str oai:repositorioacademico.upc.edu.pe:10757/313901
network_acronym_str UUPC
network_name_str UPC-Institucional
repository_id_str 2670
dc.title.eng.fl_str_mv Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
title Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
spellingShingle Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
Weilg Espejo, Pablo
Viral genotypes
Epidemiology
Acute gastroenteritis
Peru
title_short Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
title_full Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
title_fullStr Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
title_full_unstemmed Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
title_sort Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
author Weilg Espejo, Pablo
author_facet Weilg Espejo, Pablo
Orellana Peralta, Fiorella
Cornejo Pacheres, Hernán
Del Valle, Luis J.
Cornejo Tapia, Ángela
Bazán Mayra, Jorge
Ruiz, Joaquim
Del Valle Mendoza, Juana
author_role author
author2 Orellana Peralta, Fiorella
Cornejo Pacheres, Hernán
Del Valle, Luis J.
Cornejo Tapia, Ángela
Bazán Mayra, Jorge
Ruiz, Joaquim
Del Valle Mendoza, Juana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Weilg Espejo, Pablo
Orellana Peralta, Fiorella
Cornejo Pacheres, Hernán
Del Valle, Luis J.
Cornejo Tapia, Ángela
Bazán Mayra, Jorge
Ruiz, Joaquim
Del Valle Mendoza, Juana
dc.subject.eng.fl_str_mv Viral genotypes
Epidemiology
Acute gastroenteritis
Peru
topic Viral genotypes
Epidemiology
Acute gastroenteritis
Peru
description Artículo sustentado el 30 de Enero 2014 para la obtención del título profesional Médico Cirujano en la Escuela de Medicina, Facultad de Ciencias de la Salud. Universidad Peruana de Ciencias Aplicadas - UPC.
publishDate 2014
dc.date.accessioned.es_PE.fl_str_mv 2014-03-11T03:08:32Z
dc.date.available.es_PE.fl_str_mv 2014-03-11T03:08:32Z
dc.date.issued.fl_str_mv 2014-03-10
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.eng.fl_str_mv Trans R Soc Trop Med Hyg first published online April 27, 2014. doi:10.1093/trstmh/tru059
dc.identifier.issn.es_PE.fl_str_mv 1878-3503
dc.identifier.doi.eng.fl_str_mv 10.1093/trstmh/tru059
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/313901
dc.identifier.eissn.es_PE.fl_str_mv 0035-9203
identifier_str_mv Trans R Soc Trop Med Hyg first published online April 27, 2014. doi:10.1093/trstmh/tru059
1878-3503
10.1093/trstmh/tru059
0035-9203
url http://hdl.handle.net/10757/313901
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.eng.fl_str_mv http://www.ncbi.nlm.nih.gov/pubmed/24778205
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.eng.fl_str_mv application/pdf
application/msword
dc.publisher.eng.fl_str_mv Oxford University Press
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/7/MANUSCRITO_TESIS_WEILP.pdf
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/1/TESIS_VERSION_FINAL_WEILG.pdf
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/2/MANUSCRITO_TESIS_WEILG.docx
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/3/license.txt
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/4/MANUSCRITO_TESIS_WEILG.docx.txt
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/5/TESIS_VERSION_FINAL_WEILG.pdf.txt
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/8/MANUSCRITO_TESIS_WEILP.pdf.txt
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/9/MANUSCRITO_TESIS_WEILP.pdf.jpg
https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/10/TESIS_VERSION_FINAL_WEILG.pdf.jpg
bitstream.checksum.fl_str_mv 3cb1486ce65305451075fa1d8f96d1ce
201c423cfee8945bc0063d57debc1f70
9e45256313d272d26bfd2de2e19ec065
1ed8f33c5404431ad7aabc05080746c5
8c4c1ac2ef83765320687431aa40284a
b5250d04125c51f63cf561fe8541f405
f63b8f831f97ef80fd9bf3c9f4aa5efc
606a11e2769588b48a311383a5c61e4a
be092a490d2a012245fa620fa399d80c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio académico upc
repository.mail.fl_str_mv upc@openrepository.com
_version_ 1846065275235991552
spelling Weilg Espejo, PabloOrellana Peralta, FiorellaCornejo Pacheres, HernánDel Valle, Luis J.Cornejo Tapia, ÁngelaBazán Mayra, JorgeRuiz, JoaquimDel Valle Mendoza, Juana2014-03-11T03:08:32Z2014-03-11T03:08:32Z2014-03-10Trans R Soc Trop Med Hyg first published online April 27, 2014. doi:10.1093/trstmh/tru0591878-350310.1093/trstmh/tru059http://hdl.handle.net/10757/3139010035-9203Artículo sustentado el 30 de Enero 2014 para la obtención del título profesional Médico Cirujano en la Escuela de Medicina, Facultad de Ciencias de la Salud. Universidad Peruana de Ciencias Aplicadas - UPC.Artículo publicado el 27 de Abril de 2014 en la Revista Transactions of the Royal Society of Tropical Medicine & Hygiene (Oxford University Press).Background: Gastroenteritis by rotavirus is responsible for approximately 810 annual deaths/year in children under 5 years in Peru and emerging rotavirus genotypes have led to concerns regarding cross-protection by the vaccines available. Moreover, there are no reports on the molecular-epidemiology of rotavirus diarrhea in Peru Methodology: A total of 131 stool samples were obtained from children under 5 years old hospitalized from January 2010 to December 2012 in the Hospital Regional de Cajamarca, Peru. ELISA and RT-PCR techniques were performed for rotavirus detection. G and P typing of rotavirus-positive samples were obtained by semi-nested multiplex RT-PCR and sequencing was performed to confirm the PCR results. Results: Of the 117 samples available, 18.80% (22/117) tested positive for rotavirus by ELISA and 35.90% (42/117) by RT-PCR. Among the G-genotype identified, G9 in 35.71% (15/42) and G12 in 33.33% (14/42) were the most prevalent. With the most common combination being G12/P6 in 23.81% (10/42). Conclusions: A high prevalence of the G12/P6 genotype was detected. It is know that this genotype is not covered by the current vaccines available. More in depth studies are needed to know the current rotavirus genotypes presents in Peru.Revisión por paresapplication/pdfapplication/mswordengOxford University Presshttp://www.ncbi.nlm.nih.gov/pubmed/24778205info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCViral genotypes1d7716c3-1b7d-459c-9263-c596b859259c600Epidemiologya8d335ec-70c0-44c0-8786-b6adc59d012a600Acute gastroenteritis6d92f3e8-c22a-47bd-bc7f-07a7d90e7d77600Perud6e19394-1ad0-4de6-8bb9-5ec7e2e6d476600Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypesinfo:eu-repo/semantics/article2018-06-18T23:40:51ZBackground: Gastroenteritis by rotavirus is responsible for approximately 810 annual deaths/year in children under 5 years in Peru and emerging rotavirus genotypes have led to concerns regarding cross-protection by the vaccines available. Moreover, there are no reports on the molecular-epidemiology of rotavirus diarrhea in Peru Methodology: A total of 131 stool samples were obtained from children under 5 years old hospitalized from January 2010 to December 2012 in the Hospital Regional de Cajamarca, Peru. ELISA and RT-PCR techniques were performed for rotavirus detection. G and P typing of rotavirus-positive samples were obtained by semi-nested multiplex RT-PCR and sequencing was performed to confirm the PCR results. Results: Of the 117 samples available, 18.80% (22/117) tested positive for rotavirus by ELISA and 35.90% (42/117) by RT-PCR. Among the G-genotype identified, G9 in 35.71% (15/42) and G12 in 33.33% (14/42) were the most prevalent. With the most common combination being G12/P6 in 23.81% (10/42). Conclusions: A high prevalence of the G12/P6 genotype was detected. It is know that this genotype is not covered by the current vaccines available. More in depth studies are needed to know the current rotavirus genotypes presents in Peru.ORIGINALMANUSCRITO_TESIS_WEILP.pdfMANUSCRITO_TESIS_WEILP.pdfapplication/pdf117017https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/7/MANUSCRITO_TESIS_WEILP.pdf3cb1486ce65305451075fa1d8f96d1ceMD57trueTESIS_VERSION_FINAL_WEILG.pdfTESIS_VERSION_FINAL_WEILG.pdfapplication/pdf554649https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/1/TESIS_VERSION_FINAL_WEILG.pdf201c423cfee8945bc0063d57debc1f70MD51falseMANUSCRITO_TESIS_WEILG.docxMANUSCRITO_TESIS_WEILG.docxapplication/vnd.openxmlformats-officedocument.wordprocessingml.document53645https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/2/MANUSCRITO_TESIS_WEILG.docx9e45256313d272d26bfd2de2e19ec065MD52falseLICENSElicense.txtlicense.txttext/plain; charset=utf-81659https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/3/license.txt1ed8f33c5404431ad7aabc05080746c5MD53falseTEXTMANUSCRITO_TESIS_WEILG.docx.txtMANUSCRITO_TESIS_WEILG.docx.txtExtracted texttext/plain27359https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/4/MANUSCRITO_TESIS_WEILG.docx.txt8c4c1ac2ef83765320687431aa40284aMD54falseTESIS_VERSION_FINAL_WEILG.pdf.txtTESIS_VERSION_FINAL_WEILG.pdf.txtExtracted Texttext/plain30190https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/5/TESIS_VERSION_FINAL_WEILG.pdf.txtb5250d04125c51f63cf561fe8541f405MD55falseMANUSCRITO_TESIS_WEILP.pdf.txtMANUSCRITO_TESIS_WEILP.pdf.txtExtracted Texttext/plain27450https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/8/MANUSCRITO_TESIS_WEILP.pdf.txtf63b8f831f97ef80fd9bf3c9f4aa5efcMD58falseTHUMBNAILMANUSCRITO_TESIS_WEILP.pdf.jpgMANUSCRITO_TESIS_WEILP.pdf.jpgGenerated Thumbnailimage/jpeg36948https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/9/MANUSCRITO_TESIS_WEILP.pdf.jpg606a11e2769588b48a311383a5c61e4aMD59falseTESIS_VERSION_FINAL_WEILG.pdf.jpgTESIS_VERSION_FINAL_WEILG.pdf.jpgGenerated Thumbnailimage/jpeg32120https://repositorioacademico.upc.edu.pe/bitstream/10757/313901/10/TESIS_VERSION_FINAL_WEILG.pdf.jpgbe092a490d2a012245fa620fa399d80cMD510falseCONVERTED2_82532010757/313901oai:repositorioacademico.upc.edu.pe:10757/3139012019-08-30 08:11:12.378Repositorio académico upcupc@openrepository.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
score 13.982926
Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

Ejemplares Similares