Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Detalles Bibliográficos
Autores: Deshpande, Abhishek, Pasupuleti, Vinay, Thota, Priyaleela, Pant, Chaitanya, Rolston, David D K, Hernandez, Adrian V., Donskey, Curtis J, Fraser, Thomas G
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/608263
Enlace del recurso:http://hdl.handle.net/10757/608263
Nivel de acceso:acceso abierto
Materia:Clostridium difficile
Enterocolitis
Humans
Recurrence
Risk Factors
Enterocolitis, Pseudomembranous
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network_acronym_str UUPC
network_name_str UPC-Institucional
repository_id_str 2670
dc.title.es_PE.fl_str_mv Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
title Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
spellingShingle Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
Deshpande, Abhishek
Clostridium difficile
Enterocolitis
Humans
Recurrence
Risk Factors
Clostridium difficile
Enterocolitis, Pseudomembranous
Humans
Recurrence
Risk Factors
title_short Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
title_full Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
title_fullStr Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
title_full_unstemmed Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
title_sort Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
author Deshpande, Abhishek
author_facet Deshpande, Abhishek
Pasupuleti, Vinay
Thota, Priyaleela
Pant, Chaitanya
Rolston, David D K
Hernandez, Adrian V.
Donskey, Curtis J
Fraser, Thomas G
author_role author
author2 Pasupuleti, Vinay
Thota, Priyaleela
Pant, Chaitanya
Rolston, David D K
Hernandez, Adrian V.
Donskey, Curtis J
Fraser, Thomas G
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Deshpande, Abhishek
Pasupuleti, Vinay
Thota, Priyaleela
Pant, Chaitanya
Rolston, David D K
Hernandez, Adrian V.
Donskey, Curtis J
Fraser, Thomas G
dc.subject.es_PE.fl_str_mv Clostridium difficile
Enterocolitis
Humans
Recurrence
Risk Factors
topic Clostridium difficile
Enterocolitis
Humans
Recurrence
Risk Factors
Clostridium difficile
Enterocolitis, Pseudomembranous
Humans
Recurrence
Risk Factors
dc.subject.mesh.es_PE.fl_str_mv Clostridium difficile
Enterocolitis, Pseudomembranous
Humans
Recurrence
Risk Factors
description El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2016-05-04T17:57:55Z
dc.date.available.es_PE.fl_str_mv 2016-05-04T17:57:55Z
dc.date.issued.fl_str_mv 2015-04
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis. 2015, 36 (4):452-60 Infect Control Hosp Epidemiol
dc.identifier.issn.es_PE.fl_str_mv 1559-6834
dc.identifier.pmid.es_PE.fl_str_mv 25626326
dc.identifier.doi.es_PE.fl_str_mv 10.1017/ice.2014.88
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/608263
dc.identifier.journal.es_PE.fl_str_mv Infection control and hospital epidemiology (Infect Control Hosp Epidemiol)
identifier_str_mv Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis. 2015, 36 (4):452-60 Infect Control Hosp Epidemiol
1559-6834
25626326
10.1017/ice.2014.88
Infection control and hospital epidemiology (Infect Control Hosp Epidemiol)
url http://hdl.handle.net/10757/608263
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.ncbi.nlm.nih.gov/pubmed/25626326
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Cambridge University Press
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/608263/1/license.txt
bitstream.checksum.fl_str_mv 1ed8f33c5404431ad7aabc05080746c5
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Repositorio académico upc
repository.mail.fl_str_mv upc@openrepository.com
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spelling Deshpande, AbhishekPasupuleti, VinayThota, PriyaleelaPant, ChaitanyaRolston, David D KHernandez, Adrian V.Donskey, Curtis JFraser, Thomas G2016-05-04T17:57:55Z2016-05-04T17:57:55Z2015-04Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis. 2015, 36 (4):452-60 Infect Control Hosp Epidemiol1559-68342562632610.1017/ice.2014.88http://hdl.handle.net/10757/608263Infection control and hospital epidemiology (Infect Control Hosp Epidemiol)El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.OBJECTIVE: An estimated 20-30% of patients with primary Clostridium difficile infection (CDI) develop recurrent CDI (rCDI) within 2 weeks of completion of therapy. While the actual mechanism of recurrence remains unknown, a variety of risk factors have been suggested and studied. The aim of this systematic review and meta-analysis was to evaluate current evidence on the risk factors for rCDI. DESIGN: We searched MEDLINE and 5 other databases for subject headings and text related to rCDI. All studies investigating risk factors of rCDI in a multivariate model were eligible. Information on study design, patient population, and assessed risk factors were collected. Data were combined using a random-effects model and pooled relative risk ratios (RRs) were calculated. RESULTS: A total of 33 studies (n=18,530) met the inclusion criteria. The most frequent independent risk factors associated with rCDI were age≥65 years (risk ratio [RR], 1.63; 95% confidence interval [CI], 1.24-2.14; P=.0005), additional antibiotics during follow-up (RR, 1.76; 95% CI, 1.52-2.05; P<.00001), use of proton-pump inhibitors (PPIs) (RR, 1.58; 95% CI, 1.13-2.21; P=.008), and renal insufficiency (RR, 1.59; 95% CI, 1.14-2.23; P=.007). The risk was also greater in patients previously on fluoroquinolones (RR, 1.42; 95% CI, 1.28-1.57; P<.00001). CONCLUSIONS: Multiple risk factors are associated with the development of rCDI. Identification of modifiable risk factors and judicious use of antibiotics and PPI can play an important role in the prevention of rCDI.application/pdfengCambridge University Presshttp://www.ncbi.nlm.nih.gov/pubmed/25626326info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCClostridium difficileed78728c-4a26-4fde-9901-99f90e6cbcd6600Enterocolitisea54bcb6-d5e8-40d8-aa30-8638dbc31d23600Humans6568577a-3ec7-4f98-a589-9e74837db698600Recurrencec0f88e55-c90b-4273-9077-fe9a041251e3600Risk Factors8f70e09b-d838-48f3-b79a-465c917e37b4600Clostridium difficileEnterocolitis, PseudomembranousHumansRecurrenceRisk FactorsRisk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.info:eu-repo/semantics/articleOBJECTIVE: An estimated 20-30% of patients with primary Clostridium difficile infection (CDI) develop recurrent CDI (rCDI) within 2 weeks of completion of therapy. While the actual mechanism of recurrence remains unknown, a variety of risk factors have been suggested and studied. The aim of this systematic review and meta-analysis was to evaluate current evidence on the risk factors for rCDI. DESIGN: We searched MEDLINE and 5 other databases for subject headings and text related to rCDI. All studies investigating risk factors of rCDI in a multivariate model were eligible. Information on study design, patient population, and assessed risk factors were collected. Data were combined using a random-effects model and pooled relative risk ratios (RRs) were calculated. RESULTS: A total of 33 studies (n=18,530) met the inclusion criteria. The most frequent independent risk factors associated with rCDI were age≥65 years (risk ratio [RR], 1.63; 95% confidence interval [CI], 1.24-2.14; P=.0005), additional antibiotics during follow-up (RR, 1.76; 95% CI, 1.52-2.05; P<.00001), use of proton-pump inhibitors (PPIs) (RR, 1.58; 95% CI, 1.13-2.21; P=.008), and renal insufficiency (RR, 1.59; 95% CI, 1.14-2.23; P=.007). The risk was also greater in patients previously on fluoroquinolones (RR, 1.42; 95% CI, 1.28-1.57; P<.00001). CONCLUSIONS: Multiple risk factors are associated with the development of rCDI. Identification of modifiable risk factors and judicious use of antibiotics and PPI can play an important role in the prevention of rCDI.LICENSElicense.txtlicense.txttext/plain; charset=utf-81659https://repositorioacademico.upc.edu.pe/bitstream/10757/608263/1/license.txt1ed8f33c5404431ad7aabc05080746c5MD51false10757/608263oai:repositorioacademico.upc.edu.pe:10757/6082632019-08-30 07:46:18.691Repositorio académico upcupc@openrepository.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Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
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